Nodular gastritis with Helicobacter pylori infection is strongly associated with diffuse-type gastric cancer in young patients
Nodular gastritis with Helicobacter pylori infection is strongly associated with diffuse-type gastric cancer in young patients
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DOI：
10.1111/j.1443-1661.2007.00750.x
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发表时间：
2007-10-01
影响因子：
5.3
通讯作者：
Haruma, Ken
中科院分区：
文献类型：
--
作者：
Kamad, Tomoari;Tanaka, Aki;Haruma, Ken
背景：结节性胃炎（NG）是一种特殊类型的胃炎，现在被定义为胃窦结节。最近的研究表明NG与幽门螺杆菌感染密切相关，我们最近表明它可能与胃体弥漫型胃癌有关。我们回顾性调查了29岁及以下患者中NG与胃癌的关系。 患者和方法：研究组包括150名经内镜诊断为NG且年龄小于29岁的患者（男性48例，女性102例，平均年龄27.7岁）； 3939 例性别和年龄匹配的幽门螺杆菌阳性的无 NG 患者作为对照组（男性 1184 例，女性 2755 例；平均年龄 27.5 岁）。我们评估了 NG 患者相对于非 NG 患者发生胃癌的风险。结果：NG 患者的胃癌患病率显着高于对照患者（7/150；4.7% vs 3/3939；0.08%，P < 0.001）。 NG 患者患胃癌风险的优势比为 64.2（95% 置信区间；16.4-250.9）。 7例NG胃癌表现出相同的特点：组织学诊断均为弥漫型，且均位于幽门螺杆菌感染的胃体。结论：幽门螺杆菌感染的NG与年轻患者胃体弥漫型胃癌密切相关。
Background: Nodular gastritis (NG), a particular type of gastritis, is now defined as antral nodularity. Recent studies have shown that NG is strongly associated with Helicobacter pylori infection, and we recently showed that it may be associated with diffuse-type gastric cancer of the corpus. We retrospectively investigated the relation between NG and gastric cancer in patients aged 29 years or less.Patients and Methods: The study group comprised 150 patients (48 males, 102 females; mean age, 27.7 years) who were endoscopically diagnosed with NG and were less than 29 years of age; 3939 sex- and age-matched patients without NG who were H. pylori-positive served as the control group (1184 males, 2755 females; mean age, 27.5 years). We estimated the risk of gastric cancer development in patients with NG relative to that of patients without NG.Results: The prevalence of gastric cancer was significantly higher in patients with NG than in the control patients (7/150; 4.7% vs 3/3939; 0.08%, P < 0.001). The odds ratio for the risk of gastric cancer in patients with NG was found to be 64.2 (95% confidence interval; 16.4-250.9). The seven cases of gastric cancer with NG showed the same characteristics: all were diagnosed histologically as the diffuse type and were located in the corpus with H. pylori infection.Conclusion: NG with H. pylori infection is strongly associated with diffuse-type gastric cancer of the corpus in young patients.