Mammary gland development & breast cancer; connecting the dots by non-coding RNAs.
Mammary gland development & breast cancer; connecting the dots by non-coding RNAs.
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乳腺发育
DOI：
10.1007/s10911-012-9248-2
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发表时间：
2012
影响因子：
2.5
通讯作者：
Rosen,JeffreyM
中科院分区：
文献类型：
--
作者：
Behbod,Fariba;Rosen,JeffreyM
一个有趣的发现是，称为microRNA的小的非编码RNA在调节癌症中起着关键作用，这一发现使许多人转向寻找其他类型的非编码RNA的这种作用。这些其他类型的非蛋白质编码RNA包括转录的超保守区（T-UCR）、小核仁RNA（snoRNA）、PIWI相互作用RNA（piRNA）、大基因间非编码RNA（lincRNA）和长非编码RNA（lncRNA）的异质组。我们现在正处于冰山一角，并且正处于一个激动人心的时刻，通过阐明非编码RNA的作用，开始最终将正常乳腺发育和乳腺癌之间的联系联系起来。这代表了理解正常发育过程中基因调控以及这些调控过程如何在乳腺癌中改变的下一个主要前沿。我们很幸运地汇集了该领域的一些杰出专家，以审查当前的知识，并分享他们对这一令人兴奋的新领域的看法和研究。
The intriguing discovery that small non-coding RNAs called microRNAs played a key role in regulating cancer turned many heads towards finding such roles for other types of non-coding RNAs. These other types of non protein coding RNAs include transcribed ultraconserved regions (T-UCRs), small nucleolar RNAs (snoRNA), PIWI-interacting RNAs (piRNAs), large intergenic non-coding RNAs (lincRNAs) and the heterogeneous group of long non-coding RNAs (lncRNAs). We are now at the tip of the iceberg and in an exciting time to begin to finally connect the dots between normal mammary development and breast cancer by elucidating the roles of non-coding RNAs. This represents the next major frontier in understanding gene regulation during normal development and how these regulatory processes have been altered in breast cancer. We have been fortunate to bring together a number of outstanding experts in the field to review the current knowledge and share their views and research on this exciting new field.