Atopy in children of families with an anthroposophic lifestyle
Atopy in children of families with an anthroposophic lifestyle
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DOI：
10.1016/s0140-6736(98)09344-1
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发表时间：
1999-05-01
期刊：
影响因子：
168.9
通讯作者：
Pershagen, G
中科院分区：
文献类型：
--
作者：
Alm, JS;Swartz, J;Pershagen, G
背景 儿童特应性疾病患病率的增加可能与儿童感染类型、疫苗接种计划和肠道菌群的变化有关。遵循人智生活方式的人限制性地使用抗生素，很少接种疫苗，他们的饮食通常含有活乳酸杆菌，这可能会影响肠道菌群。我们的目的是研究人智家庭儿童特应性的患病率以及人智生活方式对特应性患病率的影响。在一项横断面研究中，对瑞典斯德哥尔摩附近两所人智学 (Steiner) 学校的 295 名 5-13 岁儿童与邻近两所学校的 380 名同龄儿童进行了比较，包括特应性和传染病的病史、抗生素和疫苗的使用以及社会和环境变量。我们对 13 种常见过敏原进行了皮肤点刺测试，并采集了儿童及其父母的血液样本，用于分析过敏原特异性血清 IgE 抗体。调查结果在斯坦纳学校，52% 的儿童过去曾使用过抗生素，而对照学校的这一比例为 90%。分别有 18% 和 93% 的儿童接种了麻疹、腮腺炎和风疹联合疫苗，施泰纳学校有 61% 的儿童患有麻疹。施泰纳学校 63% 的儿童食用含有活乳酸杆菌的发酵蔬菜，而对照学校的这一比例为 4.5%。皮肤点刺测试和血液测试表明，来自斯坦纳学校的儿童的特应性患病率低于对照组（比值比 0.62 [95% CI 0.43-0.91]）。人智生活方式特征的数量与特应性风险之间存在反比关系（趋势p = 0.01）。 解释 人智家庭儿童的特应性患病率低于其他家庭的儿童。与人智学相关的生活方式因素可能会降低儿童时期发生特应性的风险。
Background Increased prevalence of atopic disorders in children may be associated with changes in types of childhood infections, vaccination programmes, and intestinal microflora. People who follow an anthroposophic way of life use antibiotics restrictively, have few vaccinations, and their diet usually contains live lactobacilli, which may affect the intestinal microflora. We aimed to study the prevalence of atopy in children from anthroposophic families and the influence of an anthroposophic lifestyle on atopy prevalence. have few liveMethods In a cross-sectional study, 295 children aged 5-13 years at two anthroposophic (Steiner) schools near Stockholm, Sweden, were compared with 380 children of the same age at two neighbouring schools in terms of history;of atopic and infectious diseases, use of antibiotics and vaccinations, and social and environmental variables. Skin-prick tests were done for 13 common allergens, and we took blood samples from children and their parents for analysis of allergen-specific serum IgE-antibodies.Findings At the Steiner schools, 52% of the children had had antibiotics in the past, compared with 90% in the control schools. 18% and 93% of children, respectively, had had combined immunisation against measles, mumps, and rubella, and 61% of the children at the Steiner schools had had measles. Fermented vegetables, containing live lactobacilli, were consumed by 63% of the children at Steiner schools, compared with 4.5% at the control schools. Skin-prick tests and blood tests showed that-the children from Steiner schools had lower prevalence of atopy than controls (odds ratio 0.62 [95% CI 0.43-0.91]). There was an inverse relation between the number of characteristic features of an anthroposophic lifestyle and risk of atopy (p for trend=0.01).Interpretation Prevalence of atopy is lower in children from anthroposophic families than in children from other families. Lifestyle factors associated with anthroposophy may lessen the risk of atopy in childhood.