TREK-1 is a heat-activated background K+ channel
TREK-1 is a heat-activated background K+ channel
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DOI：
10.1093/emboj/19.11.2483
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发表时间：
2000-06-01
期刊：
影响因子：
11.4
通讯作者：
Honoré, E
中科院分区：
文献类型：
--
作者：
Maingret, F;Lauritzen, I;Honoré, E
外周和中枢温度感受器分别参与感知环境温度和体温。专门的冷和热受体存在于背根神经节感觉纤维以及前/视前下丘脑中。双孔结构域机械门控K+通道TREK-1在这些区域内高度表达。此外，TREK-1通过加热逐渐且可逆地打开。10摄氏度的上升将TREK-1电流幅度提高了约7倍。前列腺素E2和cAMP是外周和中枢温度感受器的强增敏剂，通过蛋白激酶A介导的Ser 333磷酸化逆转TREK-1的热开放。TREK-1在外周感觉神经元以及中枢下丘脑神经元中的表达使得该K+通道成为生理性温度感受器的理想候选者。
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as well as in the anterior/preoptic hypothalamus. The two-pore domain mechano-gated K+ channel TREK-1 is highly expressed within these areas. Moreover, TREK-1 is opened gradually and reversibly by heat. A 10 degrees C rise enhances TREK-1 current amplitude by similar to 7-fold. Prostaglandin E2 and cAMP, which are strong sensitizers of peripheral and central thermoreceptors, reverse the thermal opening of TREK-1 via protein kinase A-mediated phosphorylation of Ser333. Expression of TREK-1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K+ channel an ideal candidate as a physiological thermoreceptor.