O-linked mucin-type glycosylation in breast cancer.
O-linked mucin-type glycosylation in breast cancer.
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DOI：
10.1042/bst20170483
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发表时间：
2018-08-20
影响因子：
3.9
通讯作者：
Tajadura-Ortega V
中科院分区：
文献类型：
--
作者：
Burchell JM;Beatson R;Graham R;Taylor-Papadimitriou J;Tajadura-Ortega V
在超过90%的乳腺癌中观察到粘蛋白型O-连接糖基化的变化，其中经常观察到唾液酸化增加，并且经常观察到从支链聚糖到直链聚糖的变化。涉及许多机制，包括糖基转移酶的表达增加/改变和负责添加第一种糖N-乙酰基-d-半乳糖胺的酶重新定位到内质网。现在越来越清楚的是，这些变化可以通过免疫细胞上表达的聚糖敏感凝集素调节微环境，通过调节与肿瘤表面受体的相互作用以及通过结合选择素来促进肿瘤的生长和进展。了解粘蛋白型O-连接糖基化的变化如何影响肿瘤的生长和进展，揭示了乳腺癌治疗干预的新的潜在靶点。
Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen. There are many mechanisms involved including increased/altered expression of glycosyltransferases and relocalisation to the endoplasmic reticulum of the enzymes responsible for the addition of the first sugar, N-acetyl-d-galactosamine. It is now becoming clear that these changes can contribute to tumour growth and progression by modulating the micro-environment through glycan-sensing lectins expressed on immune cells, by modulating interactions with tumour surface receptors and by binding to selectins. The understanding of how changes in mucin-type O-linked glycosylation influence tumour growth and progression reveals new potential targets for therapeutic intervention in the treatment of breast cancer.