Expression of semaphorin 6D in gastric carcinoma and its significance
Expression of semaphorin 6D in gastric carcinoma and its significance
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信号蛋白6D在胃癌中的表达及其意义
DOI：
10.3748/wjg.v12.i45.7388
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发表时间：
2006-12-07
影响因子：
4.3
通讯作者：
Li, Yu-Hong
中科院分区：
文献类型：
--
作者：
Zhao, Xiang-Yang;Chen, Lin;Li, Yu-Hong
目的：探讨信号素6D在胃癌中的蛋白质及mRNA表达及其意义。
方法：分别采用半定量逆转录聚合酶链反应和蛋白质印迹法检测30例胃癌组织及正常胃黏膜中信号素6D的蛋白质及mRNA表达。
结果：胃癌组织中信号素6D的蛋白质及mRNA表达显著高于正常胃黏膜（0.24±0.06比0.19±0.07，0.26±0.09比0.20±0.10，P<0.05）。
结论：信号素6D可能在胃癌的发生和发展中起重要作用，并与肿瘤血管生成有关。（c）2006年WIG出版社。版权所有。
AIM: To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.METHODS: The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative reverse transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.RESULTS: The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 +/- 0.06 vs 0.19 +/- 0.07, 0.26 +/- 0.09 vs 0.20 +/- 0.10, P < 0.05).CONCLUSION: Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis. (c) 2006 The WIG Press. All rights reserved.