[Effects of mao-bushi-saishin-to (MBST) on experimental allergic models in rats].
[Effects of mao-bushi-saishin-to (MBST) on experimental allergic models in rats].
复制标题
[mao-bushi-saishin-to (MBST) 对大鼠实验性过敏模型的影响]。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
K. Ohata
中科院分区：
文献类型：
--
作者：
H. Shibata;S. Kohno;K. Ohata
观察了口服MBST对大鼠48小时同种被动皮肤过敏反应（PCA）和变应性鼻炎的影响。连续5天给予MBST（1，000 mg/kg/天），并在抗原激发前1天末次给药，对PCA无影响。然而，当在抗原攻击前1小时单独给予药物（1，000 mg/kg）时，反应被显著抑制。药物（1，000 mg/kg，抗原激发前1小时）倾向于减少抗原导致的染料渗漏到鼻腔中，但对过敏性组胺释放到鼻腔中没有影响。发现配方中抑制染料渗漏的中草药成分为毛。然而，毛中含有大量的l-麻黄碱和d-伪麻黄碱，对染料渗漏的抑制作用没有贡献。这些结果表明，MBST可能是治疗过敏性疾病，包括鼻炎，通过其他机制比组胺释放的抑制。
Effects of oral administration of MBST on 48 hr homologous passive cutaneous anaphylaxis (PCA) and allergic rhinitis in rats were examined. Administration of MBST (1,000 mg/kg/day) for 5 consecutive days with the final dosing at 1 day before antigen challenge did not effect on PCA. However, the reaction was significantly inhibited when the drug (1,000 mg/kg) was singly given 1 hr before antigen challenge. The drug (1,000 mg/kg, 1 hr prior to antigen challenge) tended to reduce the dye leakage into nasal cavities by antigen, while it did not affect on the anaphylactic histamine release into the cavities. The component of the chinese plants in the formula inhibiting the dye leakage was found to be Mao. However, l-ephedrine and d-pseudoephedrine, which are contained in Mao in a large amount, did not contribute to the inhibiting effect on dye leakage. These results suggest that MBST may be therapeutically effective for atopic disease including rhinitis, through the mechanism other than the inhibition of histamine release.