Form and function of the bacterial cytokinetic ring
Form and function of the bacterial cytokinetic ring
复制标题
DOI：
10.1016/j.ceb.2013.08.006
复制
发表时间：
2014-02-01
影响因子：
7.5
通讯作者：
Goley, Erin D.
中科院分区：
文献类型：
--
作者：
Meier, Elizabeth L.;Goley, Erin D.
细菌胞质分裂依赖于微管蛋白样 GTP 酶 FtsZ，它在细胞中部聚合成环形结构（Z 环），定义了分裂位点。 Z 形环使细胞壁合成和膜裂变所需的下游机械组装成核，但也可能产生收缩力。最近的体内 FtsZ 高分辨率成像已经开始阐明 Z 环内的细丝组织。这项体内工作得到了体外 Z 环重建的补充，以证明 FtsZ 的力产生能力并探索其作用机制。尽管有这些技术进步，但胞质分裂是否需要 FtsZ 介导的力产生，以及 Z 环结构和收缩如何与细胞壁重塑机制相关，这些都是悬而未决的问题。
Bacterial cytokinesis depends upon the tubulin-like GTPase FtsZ, which polymerizes into an annular structure at midcell (the Z-ring) that defines the division site. The Z-ring nucleates assembly of downstream machinery required for cell wall synthesis and membrane fission, but may also generate constrictive force. Recent high-resolution imaging of FtsZ in vivo has begun to illuminate the organization of filaments within the Z-ring. This in vivo work has been complemented by reconstitution of Z-rings in vitro to demonstrate the force-generating capacity of FtsZ and explore its mechanism of action. Despite these technical advances, whether FtsZ-mediated force generation is required for cytokinesis and how Z-ring structure and constriction are mechanistically linked to cell wall remodeling are open questions.