MODULATION OF TUBULOGLOMERULAR FEEDBACK BY ANGIOTENSIN-II TYPE-1 RECEPTORS DURING THE DEVELOPMENT OF GOLDBLATT HYPERTENSION
MODULATION OF TUBULOGLOMERULAR FEEDBACK BY ANGIOTENSIN-II TYPE-1 RECEPTORS DURING THE DEVELOPMENT OF GOLDBLATT HYPERTENSION
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DOI：
10.1161/01.hyp.25.6.1232
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发表时间：
1995-06-01
期刊：
影响因子：
8.3
通讯作者：
MITCHELL, KD
中科院分区：
文献类型：
--
作者：
BRAAM, B;NAVAR, LG;MITCHELL, KD
有人提出，双肾一夹（2K1C）Goldblatt高血压大鼠对侧肾脏中血管紧张素II（Ang II）水平升高，可增强肾小管肾小球反馈反应性和近端肾小管重吸收，从而对未夹闭的肾脏产生显着的钠潴留影响。目前的研究调查了 2K1C 高血压发展早期阶段未切开肾脏中肾小管肾小球反馈反应性对 Ang II 的依赖性。在对照条件下以及全身施用 Ang II 1 型受体拮抗剂氯沙坦 (10 mg/kg) 后，评估 2K1C 大鼠未夹闭肾脏的停流压力反馈反应。在 1 周剪毛和整形手术的大鼠中，给予氯沙坦可降低平均动脉压（从 143+/-6 毫米汞柱降至 123+/-2 毫米汞柱，P
It has been suggested that the increased levels of angiotensin II (Ang II) in the contralateral kidney of two-kidney, one clip (2K1C) Goldblatt hypertensive rats act to enhance tubuloglomerular feedback responsiveness and proximal tubular reabsorption and thereby exert a substantial sodium-retaining influence on the nonclipped kidney. The current study investigated the Ang II dependency of tubuloglomerular feedback responsiveness in the nonciipped kidney during the early stages of development of 2K1C hypertension. Stop-flow pressure feedback responses were assessed in the nonclipped kidney of 2K1C rats during control conditions and after systemic administration of the Ang II type 1 receptor antagonist losartan (10 mg/kg). In 1-week clipped and shamoperated rats, losartan administration decreased mean arterial pressure (from 143+/-6 to 123+/-2 mm Hg, P