Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
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HTLV-II 的反式激活基因诱导 IL-2 受体和 IL-2 细胞基因表达。
DOI：
10.1126/science.3010456
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Haseltine,WA
中科院分区：
文献类型：
--
作者：
Greene,WC;Leonard,WJ;Wano,Y;Svetlik,PB;Peffer,NJ;Sodroski,JG;Rosen,CA;Goh,WC;Haseltine,WA
人类嗜T淋巴细胞病毒I型和II型(HTLV-I和-II)在病因学上与某些T细胞白血病和淋巴瘤有关，这些T细胞白血病和淋巴瘤的特征是表现出白细胞介素2的膜受体。这些病毒与这种生长因子受体的关系尚不清楚。将HTLV-II反式激活因子(TAT)基因导入Jurkat T淋巴样细胞系，可诱导IL-2受体和IL-2基因的表达。这些细胞基因的共同表达可能在逆转录病毒感染后改变T细胞的生长中发挥作用。
The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of thetrans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.