Characterization of ultrananocrystalline diamond microsensors for in vivo dopamine detection
Characterization of ultrananocrystalline diamond microsensors for in vivo dopamine detection
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DOI：
10.1063/1.4811785
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发表时间：
2013-06-24
影响因子：
4
通讯作者：
Garris, Paul A.
中科院分区：
文献类型：
--
作者：
Arumugam, Prabhu U.;Zeng, Hongjun;Garris, Paul A.
我们展示了在金属微丝上涂覆和微图案化掺硼超纳米晶金刚石（UNCD（R））的技术可行性，并将其应用于使用快速扫描循环伏安法检测体内多巴胺的微传感器。使用亚铁氰化钾-铁氰化物氧化还原对，UNCD电极表面一致地产生具有>800的高信噪比的电化学信号。Parylene图案化的UNCD微电极被有效地应用于检测多巴胺可靠地在体外使用流动注射分析与检测限为27 nM和在纹状体的麻醉大鼠在多巴胺神经元的电刺激过程中。(C)2013 AIP Publishing LLC.
We show the technical feasibility of coating and micro patterning boron-doped ultrananocrystalline diamond (UNCD (R)) on metal microwires and of applying them as microsensors for the detection of dopamine in vivo using fast-scan cyclic voltammetry. UNCD electrode surface consistently generated electrochemical signals with high signal-to-noise ratio of >800 using potassium ferrocyanide-ferricyanide redox couple. Parylene patterned UNCD microelectrodes were effectively applied to detect dopamine reliably in vitro using flow injection analysis with a detection limit of 27nM and in the striatum of the anesthetized rat during electrical stimulation of dopamine neurons. (C) 2013 AIP Publishing LLC.