DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
复制标题
神经发育障碍中催产素受体的 DNA 甲基化
DOI：
10.1007/s10803-020-04792-x
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
R. Weksberg
中科院分区：
文献类型：
--
作者：
M. Siu;S. Goodman;Isaac Yellan;D. Butcher;M. Jangjoo;D. Grafodatskaya;Rageen Rajendram;Y. Lou;Rujun Zhang;Chunhua Zhao;R. Nicolson;S. Georgiades;P. Szatmari;S. Scherer;W. Roberts;E. Anagnostou;R. Weksberg
许多神经发育障碍（NDD）都有共同的学习和行为障碍，以及催产素激素调节异常等特征。在这里，我们研究了自闭症谱系（ASD）、注意力缺陷多动（ADHD）和强迫症（OCD）患者催产素受体基因（OXTR）第一内含子的DNA甲基化（DNAm）。评估ASD（血液）、ADHD（唾液）、OCD（唾液）队列的OXTR的DNA m，与神经型、组织匹配的对照相比，其揭示了性别特异性DNA m差异。表现出极端DNAm值的ASD或ADHD个体分别比那些DNAm在正常范围内的个体智商更低，社会问题更多。这表明OXTR DNAm模式在NDD中改变，并且可能与常见的临床结果相关。
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes.
影响因子：
7
作者：
Shaikh, Tamim H.;Gai, Xiaowu;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
9.8
作者：
Kochinke, Korinna;Zweier, Christiane;Schenck, Annette
通讯作者：
Schenck, Annette
DOI：
10.1016/j.jaac.2009.11.011
发表时间：
2010-03-01
影响因子：
13.3
作者：
Ramtekkar, Ujjwal P.;Reiersen, Angela M.;Todd, Richard D.
通讯作者：
Todd, Richard D.