Basic symptoms in the general population and in psychotic and non-psychotic psychiatric adolescents
Basic symptoms in the general population and in psychotic and non-psychotic psychiatric adolescents
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DOI：
10.1016/j.schres.2009.03.001
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发表时间：
2009-06-01
影响因子：
4.5
通讯作者：
Resch, Franz
中科院分区：
文献类型：
--
作者：
Meng, Heiner;Schimmelmann, Benno Graf;Resch, Franz
目的：认知-知觉“基本症状”是对超高风险标准的补充，以预测精神病前期精神病的发病。其目的是调查具有代表性的一般青少年人群样本(GPS：N=96)中各种“基本症状”的患病率，并将其与首次入院的早发性精神病青少年(EOP；N=87)或非精神病精神障碍(NP；N=137)进行比较。方法：采用波恩基本症状评定量表(BSABS)对受试者进行评定。比较了三组中至少有一种“基本症状”的患病率和平均数。Logistic回归被用来通过BSABS子量表预测组成员；风险比被计算来识别最好地区分组间的“基本症状”。结果：至少有一种“基本症状”的患病率在GPS组为30.2%，在NP组为81%，在EOP组为96.5%。与GPS相比，EOP的正确率较高(94.0%)，而与NP相比(78.6%)较低。认知症状在EOP和NP之间的区别最好。结论：与其他前驱症状和精神病样经历一样，“基本症状”在一般青少年人群中普遍存在，但与EOP和NP相比，发生率较低。不建议在一般人群或未经选择的患有精神病的青少年中使用“至少一种基本症状”作为对有精神障碍风险的青少年的筛查标准。然而，特别是认知“基本症状”可能是一个有价值的标准，将被纳入未来对青少年的“风险”研究。(C)2009爱思唯尔B.V.保留所有权利。
Objective: Cognitive-perceptive 'basic symptoms' are used complementary to ultra-high-risk criteria in order to predict onset of psychosis in the pre-psychotic phase. The aim was to investigate the prevalence of a broad selection of 'basic symptoms' in a representative general adolescent population sample (GPS: N = 96) and to compare it with adolescents first admitted for early onset psychosis (EOP; N = 87) or non-psychotic psychiatric disorders (NP; N = 137). Methods: Subjects were assessed with the Bonn Scale for the Assessment of Basic Symptoms (BSABS). Prevalence of at least one 'basic symptom' and mean numbers were compared across the three groups. Logistic regression was used to predict group membership by BSABS subscales; risk ratios were calculated to identify 'basic symptoms' which best discriminated between groups. Results: The prevalence of at least any one 'basic symptom' was 30.2% in GPS compared to 81% in NP and 96.5% in EOP. Correct classification of EOP when compared to GPS was high (94.0%) and lower when compared to NP (78.6%). Cognitive symptoms discriminated best between EOP and NP. Conclusion: Alike other prodromal- and psychotic-like experiences,'basic symptoms' are prevalent in the general adolescent population, yet at a lower rate compared to EOP and NP. The usage of 'at least one basic symptom' as a screening criterion for youth at risk of developing a psychotic disorder is not recommended in the general population or in unselected psychiatrically ill adolescents. However, particularly cognitive 'basic symptoms' may be a valuable criteria to be included in future 'at risk' studies in adolescents. (C) 2009 Elsevier B.V. All rights reserved.