Essential Neuroscience in Immunology.
Essential Neuroscience in Immunology.
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DOI：
10.4049/jimmunol.1601613
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发表时间：
2017-05-01
期刊：
影响因子：
--
通讯作者：
Tracey KJ
中科院分区：
文献类型：
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作者：
Chavan SS;Tracey KJ
免疫学领域主要集中在造血细胞启动和维持先天性和适应性免疫的分子机制。最近发现，神经元信号在免疫中占据着关键的调节位置，这一发现扩大了人们关注的基础。这一发现是神经元回路反射性地调节先天免疫和适应性免疫。一个特别好的表征电路调节先天免疫，炎症反射，是依赖于动作电位传输到网状内皮系统通过迷走神经和脾神经。这一领域随着其他几种调节离散免疫功能的反射的鉴定而显着增长。如本文所述，这些机制的描述揭示了对免疫的新认识，使第一类使用生物电子设备抑制类风湿性关节炎患者细胞因子和炎症的临床试验成为可能，并提供了免疫的马赛克视图，即造血和神经对感染和损伤的反应的整合。
The field of immunology is principally focused on the molecular mechanisms by which hematopoetic cells initiate and maintain innate and adaptive immunity. That cornerstone of attention has been expanded by recent discoveries that neuronal signals occupy a critical regulatory niche in immunity. The discovery is that neuronal circuits operating reflexively regulate innate and adaptive immunity. One particularly well-characterized circuit regulating innate immunity, the inflammatory reflex, is dependent upon action potentials transmitted to the reticuloendothelial system via the vagus and splenic nerves. This field has grown significantly with identification of several other reflexes regulating discrete immune functions. As reviewed here, the delineation of these mechanisms revealed a new understanding of immunity, enabled a first in class clinical trial using bioelectronic devices to inhibit cytokines and inflammation in rheumatoid arthritis patients, and provided a mosaic view of immunity as the integration of hematopoetic and neural responses to infection and injury.