Sentinel lymph node radiolocalization in head and neck squamous cell carcinoma
Sentinel lymph node radiolocalization in head and neck squamous cell carcinoma
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DOI：
10.1097/00005537-200002010-00003
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发表时间：
2000-02-01
期刊：
影响因子：
2.6
通讯作者：
Pyle, PB
中科院分区：
文献类型：
--
作者：
Alex, JC;Sasaki, CT;Pyle, PB
目的：探讨前哨淋巴结在头颈部鳞状细胞癌NO期放射定位的可行性，了解前哨淋巴结能否作为局部微转移疾病的预后指标。研究设计：前瞻性报道8例非头颈部鳞状细胞癌前哨淋巴结放射定位的应用。方法：每例患者均在插管后立即行瘤周粘膜下注射硫磺胶体制备的滤网99m。至少30分钟后，皮肤表面标记出与前哨结节相对应的积聚焦点区域。结果：8例前哨淋巴结放射定位均能准确定位两个或两个以上前哨淋巴结。在一名患者中，三个含有微转移疾病的淋巴结中有两个是前哨淋巴结。无前哨淋巴结微转移阴性而非前哨淋巴结阳性的病例。结论：在头颈部鳞状细胞癌患者中，应用放射性标记硫胶定位前哨淋巴结是可行的。虽然头颈部鳞状细胞癌前哨淋巴结放射定位可能会减少区域淋巴结管理的时间、成本和发病率，但在确定其作用之前，还需要更多的技术经验。
Objectives: To determine the feasibility of sentinel node radiolocalization in stage NO in head and neck squamous cell carcinoma and to gain insight as to whether the sentinel node could be prognostic of regional micrometastatic disease.Study Design: A prospective report on the application sentinel node radiolocalization in eight patients with NO squamous cell carcinoma of the head and neck region.Methods: For each patient a peritumoral submucosal injection of filtered technetium (Tc-99m) prepared with sulfur colloid was performed immediately following intubation. After at least 30 minutes, focal areas of accumulation corresponding to a sentinel node were marked on the skin surface. Complete neck dissections were performed, and the sentinel nodes were identified for later histological evaluation and comparison to the remaining lymphadenectomy specimen.Results: Sentinel node radiolocalization accurately identified two or more sentinel lymph nodes in all eight cases. In one patient, two of the three lymph nodes containing micrometastatic disease were sentinel lymph nodes. There was no instance in which sentinel node was negative for micrometastatic disease while being positive in a nonsentinel lymph node.Conclusions: Accurate localization of the sentinel lymph node using radiolabeled sulfur-colloid is feasible in patients with squamous cell carcinoma of the head and neck region. Although sentinel node radiolocalization in head and neck squamous cell cancer may potentially reduce the time, cost, and morbidity of regional lymph node management, more experience with technique is required before its role can be determined.