T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
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DOI：
10.1086/374786
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发表时间：
2003-05-15
影响因子：
6.4
通讯作者：
Deeks, SG
中科院分区：
文献类型：
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作者：
Hunt, PW;Martin, JN;Deeks, SG
虽然T细胞活化与未经治疗的人类免疫缺陷病毒1型（HIV-1）感染的疾病进展有关，但其在抗逆转录病毒治疗患者中的意义尚不清楚。对99例接受抗逆转录病毒治疗期间血浆HIV RNA水平低于或等于1000拷贝/mL（中位数为21个月）的HIV感染成人进行了活化（CD 38（+）HLA-DR+）T细胞计数测定。持续病毒抑制的患者T细胞活化水平低于未经治疗的患者，但高于未感染HIV的对照组。持续性T细胞活化与治疗期间CD 4（+）T细胞增加减少相关。活化的CD 8（+）T细胞的比例每增加5%，CD 4（+）T细胞/ mm 3就会减少35。T细胞活化增加与病毒抑制持续时间缩短、丙型肝炎病毒合并感染、频繁的低水平病毒血症和较低的最低CD 4（+）T细胞计数相关。直接针对T细胞活化或活化决定因素的干预措施可能被证明是抗逆转录病毒治疗的有用佐剂。
Although T cell activation is associated with disease progression in untreated human immunodeficiency virus type 1 ( HIV-1) infection, its significance in antiretroviral- treated patients is unknown. Activated ( CD38(+) HLA-DR+) T cell counts were measured in 99 HIV-infected adults who had maintained a plasma HIV RNA level less than or equal to1000 copies/mL for a median of 21 months while receiving antiretroviral therapy. Patients with sustained viral suppression had lower levels of T cell activation than untreated patients but higher levels than HIV-uninfected control subjects. Persistent T cell activation was associated with decreased CD4(+) T cell gains during therapy. For every 5% increase in the proportion of activated CD8(+) T cells, 35 fewer CD4(+) T cells/ mm(3) were gained. Increased T cell activation was associated with shorter duration of viral suppression, hepatitis C virus coinfection, frequent low-level viremia, and lower nadir CD4(+) T cell counts. Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy.