Birth weight and perfluorooctane sulfonic acid: a random-effects meta-regression analysis.
Birth weight and perfluorooctane sulfonic acid: a random-effects meta-regression analysis.
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DOI：
10.1097/ee9.0000000000000095
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发表时间：
2020-06
期刊：
影响因子：
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通讯作者：
Longnecker MP
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文献类型：
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作者：
Dzierlenga MW;Crawford L;Longnecker MP
补充数字内容可在文本中找到。全氟辛烷磺酸（PFOS）是一种普遍存在的环境污染物。发达国家的大多数人都有可检测的血清浓度。世界各地的研究表明，出生体重较轻与血清中的全氟辛烷磺酸有关，其中许多研究最近才发表。为了便于对出生体重和全氟辛烷磺酸之间的关联进行因果评估，我们更新了之前对该关联的荟萃分析，并采用了一种便于将所有可用数据纳入一项分析的方法。我们的分析基于29项研究的观察结果。随机效应总结为−3.22 g/ng/ml（95%置信区间[CI] = −5.11，−1.33）。在一项按怀孕时间对全氟辛烷磺酸浓度进行分层的亚组分析中，早期组的汇总值为-1.35（95% CI =-2.33，-0.37），晚期组为-7.17（95% CI =-10.93，-3.41）。在包含抽血时间项的荟萃回归模型中，截距略为正值，但基本为零（0.59 g/ng/ml，95%CI =-1.94，3.11）。换句话说，该模型表明，在怀孕初期抽血时，出生体重与全氟辛烷磺酸基本上没有关系。亚组分析的结果与模型分析的结果不同，因为早期组抽血时的平均胎龄为14周，此时仍会出现偏倚。亚洲研究中更强的逆相关性并不能完全解释为她们的血液是在怀孕后期抽取的。证据不支持或不支持因果关系。
Supplemental Digital Content is available in the text. Perfluorooctane sulfonic acid (PFOS) is a ubiquitous environmental contaminant. Most people in developed countries have detectable serum concentrations. Lower birth weight has been associated with serum PFOS in studies world-wide, many of which have been published only recently. To facilitate a causal assessment of the birth weight and PFOS association, we updated previous meta-analyses of the association and employed a method that facilitated inclusion of all available data in one analysis. Our analysis was based on observations from 29 studies. The random effects summary was −3.22 g/ng/ml (95% confidence interval [CI] = −5.11, −1.33). In a subgroup analysis stratified by when in pregnancy the PFOS concentration was measured, the summary for the early group was −1.35 (95% CI = −2.33, −0.37) and for the later group was −7.17 (95% CI = −10.93, −3.41). In a meta-regression model including a term for timing of blood draw, the intercept was slightly positive but essentially zero (0.59 g/ng/ml, 95% CI = −1.94, 3.11). In other words, the model indicated that when blood was drawn at the very beginning of pregnancy, there was essentially no relation of birth weight to PFOS. The results from the subgroup analyses differed from those from the model because the average gestational age at blood draw in the early group was 14 weeks, when bias would still be expected. A stronger inverse association in Asian studies was not completely explained by their blood draws being from later in pregnancy. The evidence was weakly or not supportive of a causal association.