Case-control study of lung cancer among sugar cane farmers in India
Case-control study of lung cancer among sugar cane farmers in India
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DOI：
10.1136/oem.56.8.548
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发表时间：
1999-08-01
影响因子：
4.9
通讯作者：
Ernst, P
中科院分区：
文献类型：
--
作者：
Amre, DK;Infante-Rivard, C;Ernst, P
目的-调查甘蔗农民和糖厂工人肺癌的风险。方法-病例对照研究是在印度马哈拉施特拉邦省主要甘蔗种植区的6家医院进行的。1996年5月至1998年4月期间，从这些医院发现了新诊断的经组织学证实的病例。其他癌症被选为对照组和匹配的情况下，年龄，性别，居住区，和时间的diagnosis. Results调整混杂因素，肺癌的风险增加，发现曾受雇于甘蔗农场的工人（优势比（OR）1.92，95%置信区间（95%CI）1.08至3.40）。发现涉及农场准备（OR 1.81，95% CI 0.99至3.27）和收获后焚烧农场（OR 1.82，95% CI 0.99至3.34）的工作风险增加。收获作物的风险没有显著增加（OR 1.41，95% CI 0.70 - 2.90）和在米尔斯中加工甘蔗（或1.70，95%CI 0.20至12.60）。结论-暴露于生物无定形二氧化硅（BAS）纤维从土壤中吸收并沉积在甘蔗作物叶片中的二氧化硅或由于BAS在高温下转化为方石英而形成的结晶二氧化硅可以解释甘蔗种植者患肺癌的风险增加。
Objectives-To investigate the risk of lung cancer among sugar cane farmers and sugar mill workers.Methods-A case-control study was conducted based in six hospitals in the predominantly sugar cane farming districts of the province of Maharashtra in India. Newly diagnosed, histologically confirmed cases were identified from these hospitals between May 1996 and April 1998. Other cancers were chosen as controls and matched to cases by age, sex, district of residence, and timing of diagnosis.Results-Adjusting for confounders, an increased risk of lung cancer was found for workers ever employed on a sugar cane farm (odds ratio (OR) 1.92, 95% confidence interval (95% CI) 1.08 to 3.40). Increased risks were found for work involving preparation of the farm (OR 1.81, 95% CI 0.99 to 3.27) and burning of the farm after harvesting (OR 1.82, 95% CI 0.99 to 3.34). Non-significant increases in risks were found for harvesting the crop (OR 1.41, 95% CI 0.70 to 2.90) and processing the cane in the mills (OR 1.70, 95% CI 0.20 to 12.60).Conclusions-Exposure to fibres of biogenic amorphous silica (BAS) formed from silica absorbed from the soil and deposited in the leaves of the sugar cane crop or crystalline silica formed as a result of conversion of BAS to cristobalite at high temperatures may account for the increased risks of lung cancer among sugar cane farmers.