Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.
Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.
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使用 IgM 或 IgD 特异性抗血清阻断体外一抗对胸腺非依赖性和胸腺依赖性抗原的反应。
DOI：
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发表时间：
1978
影响因子：
11.1
通讯作者：
Ellen S. Vitetta
中科院分区：
文献类型：
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作者：
J. C. Cambier;F. Ligler;Jonathan W. Uhr;J. Kettman;Ellen S. Vitetta
本文研究了抗MU和抗Delta抗体对小鼠脾细胞对胸腺依赖(三硝基苯化红细胞)和非胸腺依赖(三硝基苯化布鲁氏菌)形式的三硝基苯特异性IgM反应的影响。结果表明，抗MU抗体和抗Delta抗体均可阻断成人脾细胞对胸腺依赖抗原的反应。低浓度IGD的新生儿脾细胞的胸腺依赖性反应也被抗Delta治疗所消除。相反，抗MU抗体，而不是抗Delta抗体，阻断了成人脾细胞对使用的胸腺非依赖性抗原的反应。这些结果表明，IgM和IGD都是胸腺依赖抗原触发细胞所需的受体，但所用胸腺非依赖性抗原仅需要IgM受体来触发。
The effect of anti-mu and anti-delta on the primary in vitro IgM response of murine splenocytes to thymus-dependent (trinitrophenylated erythrocytes) and thymus-independent (trinitrophenylated brucella) forms of trinitrophenyl was studied. The results indicate that either anti-mu or anti-delta can block the response of adult splenocytes to the thymus-dependent antigen. The thymus-dependent responses of neonatal splenocytes that bear a low concentration of IgD were also abrogated by treatment with anti-delta. In contrast, anti-mu, but not anti-delta, blocked the response of adult splenocytes to the thymus-independent antigen used. These results indicate that both IgM and IgD are receptors required for triggering cells by a thymus-dependent antigen but that only IgM receptors are required for triggering by the thymus-independent antigen used.