Sex differences in the association between serum lipids and depressive symptoms: A longitudinal population-based study
Sex differences in the association between serum lipids and depressive symptoms: A longitudinal population-based study
复制标题
血脂与抑郁症状之间关联的性别差异：一项基于人群的纵向研究
DOI：
10.1016/j.jad.2021.05.011
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发表时间：
2021
影响因子：
6.6
通讯作者：
Song Yongfeng
中科院分区：
文献类型：
--
作者：
Xu Lu;Wang Kai;Wang Shengfeng;Liu Lili;Lv Xiaozhen;Song Yongfeng
背景：抑郁症是一个重要的全球公共卫生问题。性别差异是否存在于血脂和抑郁症状之间的关系是有争议的。本研究旨在探讨中国中老年人群中血脂异常与抑郁症状之间关系的性别差异。方法：采用中国健康与退休纵向研究的数据，包括2 630名男性和2 929名女性。采用标准酶比色法测定血脂。抑郁症状由10项流行病学研究中心抑郁量表评估。采用多变量logistic回归分别评估男性和女性血脂与抑郁症状之间的关系。为了排除高血压和糖尿病的影响，上述分析也在没有高血压和糖尿病的人群中进行。结果：总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇与抑郁症状无关。高水平甘油三酯与男性抑郁症状有显著相关性（校正OR 1.35, 95% CI 0.91 - 1.99）。在没有高血压和糖尿病的人群中，高水平的TGs仅与男性抑郁症状的发展相关（校正OR 2.04, 95% CI 1.20至3.47）。局限性：抑郁症和慢性疾病分别由CESD-10和自我报告确定，具有一定的主观性。结论：高水平甘油三酯增加了男性抑郁症状的风险，尤其是在非高血压和非糖尿病人群中。本研究为制定针对性别的抑郁症状预防策略和治疗措施提供了依据。
Background:Depression is an important global public health problem. Whether sex differences exist in the association between serum lipids and depressive symptoms is controversial. This study aimed to investigate sex differences in the association between dyslipidemia and depressive symptoms in the middle-aged and elderly population in China.Methods:Data from the China Health and Retirement Longitudinal Study, which included 2 630 males and 2 929 females, were used. Serum lipids were measured using a standard enzymatic colorimetric technique. Depressive symptoms were evaluated by the 10-item Center for Epidemiologic Studies Depression Scale. Multivariable logistic regression was performed to evaluate the association between serum lipids and depressive symptoms in men and women separately. To preclude the effects of hypertension and diabetes, the above analysis was also performed among those free of hypertension and diabetes.Results:Total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not associated with depressive symptoms. High-level triglycerides showed a marginally significant association with depressive symptoms in men (adjusted OR 1.35, 95% CI 0.91 to 1.99). In the population without hypertension and diabetes, high-levels TGs were only associated with the development of depressive symptoms in men (adjusted OR 2.04, 95% CI 1.20 to 3.47).Limitations:Depression and chronic diseases were respectively identified by CESD-10 and self-report, which were subjective to some extent.Conclusions:High-level triglycerides increased the risk of depressive symptoms in men, especially in the nonhypertensive and nondiabetic population. This study provided a basis for formulating sex-specific prevention strategies and treatment measures for depressive symptoms.