OPTICAL IMAGING OF BIPOLAR CORTICAL STIMULATION
OPTICAL IMAGING OF BIPOLAR CORTICAL STIMULATION
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DOI：
10.3171/jns.1993.78.5.0785
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发表时间：
1993-05-01
影响因子：
4.1
通讯作者：
BLASDEL, GG
中科院分区：
文献类型：
--
作者：
HAGLUND, MM;OJEMANN, GA;BLASDEL, GG
为了更好地了解双极表面刺激期间发生的皮层激活程度，作者刺激猴子视觉皮层，同时用光学成像监测激活程度。在视觉刺激过程中，猴视皮层的内在信号的光学成像导致了眼优势和方向选择性的功能图。在获得眼优势和方向偏好的功能图后，施加双极表面刺激以仅激活双极电极周围的皮层区域。刺激强度和持续时间的变化有不同程度的反应，这些结果证明了双极皮层表面刺激定位皮层功能区的可靠性。激活区域，至少在双极刺激电极周围的区域，似乎没有激活附近的眼优势柱或方向补丁。术中双极表面刺激仍然是定位罗兰皮层和基本语言部位的可靠技术。
In order to better understand the degree of cortical activation that occurs during bipolar surface stimulation, the authors stimulated monkey visual cortex while monitoring the degree of activation with optical imaging. Optical imaging of intrinsic signals in monkey visual cortex during visual stimulation resulted in functional maps of ocular dominance and orientation selectivity. After functional maps of ocular dominance and orientation preference were obtained, bipolar surface stimulation was applied to activate just the cortical areas around the bipolar electrodes. Graded responses to changes in the stimulation intensity and duration were found. These findings demonstrate the reliability of bipolar cortical surface stimulation in localizing functional regions of cortex. The area of activation, at least in the region around the bipolar stimulating electrodes, did not appear to activate nearby ocular dominance columns or orientation patches. Intraoperative bipolar surface stimulation continues to be a consistently reliable technique for localizing rolandic cortex and essential language sites.