Functional connectivity of emotional processing in depression
Functional connectivity of emotional processing in depression
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DOI：
10.1016/j.jad.2011.06.021
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发表时间：
2011-11-01
影响因子：
6.6
通讯作者：
Frodl, Thomas
中科院分区：
文献类型：
--
作者：
Carballedo, Angela;Scheuerecker, Johanna;Frodl, Thomas
目的：这项研究的目的是绘制一个情绪处理的神经网络图，并确定与健康对照组相比，严重抑郁症患者的差异。假设情绪面孔的有意知觉激活了杏仁核(Demir等人)、眶前叶皮质(OFC)、前扣带回(ACC)和前额叶皮质(PFC)之间的联系，并且额叶-杏仁核间的联系在重度抑郁障碍(MDD)中发生了改变。方法：15例非药物治疗的MDD患者和15名健康对照被纳入研究。所有受试者都使用相同的面部匹配功能磁共振成像(FMRI)任务进行评估，已知涉及这些区域。用SPM5统计参数图进行数据分析，用Marsbar提取fMRI时间序列。结果：建立了包含ACC、OFC、PFC和AMY的左右大脑半球的有效模型。在从AMY到OF11的通路上，患者左侧大脑半球的连接性强度显著低于对照组，而在从PF9到OF11的通路上，患者的连接性有更高的趋势。在右半球，患者在从AMY到OF11、从AMY到ACC和从ACC到PF9的路径上显示出较低的连接系数。相反，对照组在从ACC到AMY的路径上显示出较低的连接强度。结论：结构方程模型可以证明边缘和额叶脑区之间的功能性分离。对这些发现的解释可能是，杏仁核与额叶皮质之间存在情绪加工偏向，杏仁核与额叶皮质之间以及杏仁核与ACC之间以及ACC与前额叶皮质之间存在右侧分离，这可能与右侧大脑半球在情绪加工中的作用更为显著一致。(C)2011爱思唯尔B.V.保留所有权利。
Objectives: The aim of the study is to map a neural network of emotion processing and to identify differences in major depression compared to healthy controls. It is hypothesized that intentional perception of emotional faces activates connections between amygdala (Demir et al.), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and prefrontal cortex (PFC) and that frontal-amygdala connections are altered in major depressive disorder (MDD).Methods: Fifteen medication-free patients with MDD and fifteen healthy controls were enrolled. All subjects were assessed using the same face-matching functional Magnetic Resonance Imaging (fMRI) task, known to involve those areas. Brain activations were obtained using Statistical Parametric Mapping version 5 (SPM5) for data analysis and MARSBAR for extracting of fMRI time series. Then data was analyzed using structural equation modeling (SEM).Results: A valid model was established for the left and the right hemispheres showing a circuit involving ACC, OFC, PFC and AMY. The left hemisphere shows significant lower connectivity strengths in patients than controls, for the pathway that goes from AMY to the OF11, and a trend of higher connectivity in patients for the path that goes from the PF9 to the OF11. In the right hemisphere, patients show lower connectivity coefficients in the paths from the AMY to OF11, from the AMY to ACC, and from the ACC to PF9. By the contrary, controls show lower connectivity strengths for the path that goes from ACC to AMY.Conclusions: Functional disconnection between limbic and frontal brain regions could be demonstrated using structural equation modeling. The interpretation of these findings could be that there is an emotional processing bias with disconnection bilaterally between amygdala to orbitofrontal cortices and in addition a right disconnection between amygdala and ACC as well as between ACC and prefrontal cortex possibly in line with a more prominent role for the right hemisphere in emotion processing. (C) 2011 Elsevier B.V. All rights reserved.