Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle
Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle
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DOI：
10.1080/09168451.2016.1246173
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发表时间：
2017-02-01
影响因子：
1.6
通讯作者：
Fushiki, Tohru
中科院分区：
文献类型：
--
作者：
Kitamura, Kumiko;Takamura, Yusuke;Fushiki, Tohru
骨骼肌是控制2型糖尿病发展的重要器官。我们通过体外肌肉细胞筛选试验发现三七根具有改善高血糖的作用。人参皂苷被认为是人参的有效成分。然而，在体内，皂苷转化为达玛烷型三萜，这可能是抗高血糖活性的原因。我们开发了一种从三七根中提取达玛烷型三萜提取物（DTE）的方法，并研究了该提取物的潜在降血糖活性。结果表明，DTE对KK-A（y）小鼠血糖的抑制作用强于皂苷提取物（SE）。此外，DTE改善口服葡萄糖耐量、胰岛素敏感性、葡萄糖摄取和骨骼肌Akt磷酸化。这些结果表明，DTE是一个有前途的代理控制高血糖症，通过提高骨骼肌中的葡萄糖摄取。
Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve hyperglycemia through in vitro muscle cells screening test. Saponins are considered as the active ingredients of ginseng. However, in the body, saponins are converted to dammarane-type triterpenes, which may account for the anti-hyperglycemic activity. We developed a method for producing a dammarane-type triterpene extract (DTE) from Panax notoginseng roots and investigated the extract's potential anti-hyperglycemic activity. We found that DTE had stronger suppressive activity on blood glucose levels than the saponin extract (SE) did in KK-A(y) mice. Additionally, DTE improved oral glucose tolerance, insulin sensitivity, glucose uptake, and Akt phosphorylat ion in skeletal muscle. These results suggest that DTE is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.