Molecular Evidence of Persistent Epidemic and Evolution of Subgenotype B1 Coxsackievirus A16-Associated Hand, Foot, and Mouth Disease in China
Molecular Evidence of Persistent Epidemic and Evolution of Subgenotype B1 Coxsackievirus A16-Associated Hand, Foot, and Mouth Disease in China
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中国B1亚基因型柯萨奇病毒A16相关手足口病持续流行和演变的分子证据
DOI：
10.1128/jcm.02338-09
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发表时间：
2010-02-01
影响因子：
9.4
通讯作者：
Xu, Wenbo
中科院分区：
文献类型：
--
作者：
Zhang, Yong;Wang, Dongyan;Xu, Wenbo
1999 - 2008年中国CVA16的分子流行病学研究反映了B1亚基因型病毒中B1a和B1b聚集性共循环的模式。据估计，CVA16的年进化率约为每同义核苷酸0.91 × 10（-2）个取代/年，略低于HEV71。
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.