Usefulness of Myocardial Annular Velocity Change During Mental Stress to Predict Cardiovascular Outcome in Patients With Coronary Artery Disease (From the Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram Treatment Trial)
Usefulness of Myocardial Annular Velocity Change During Mental Stress to Predict Cardiovascular Outcome in Patients With Coronary Artery Disease (From the Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram Treatment Trial)
复制标题
DOI：
10.1016/j.amjcard.2017.07.039
复制
发表时间：
2017-11-01
影响因子：
2.8
通讯作者：
Jiang, Wei
中科院分区：
文献类型：
--
作者：
Alenezi, Fawaz;Brummett, Beverly H.;Jiang, Wei
精神应激引起的心肌缺血很常见，也是冠状动脉疾病（CAD）患者不良心血管结局的预后因素。本研究旨在探讨精神应激诱发的心肌环速度 (MAV) 与 CAD 患者心血管结局之间的关联。对 224 名临床稳定的 CAD 患者进行静息和精神压力测试时，获得了 MAV，特别是舒张早期 (e')、舒张晚期 (a') 和收缩期 (s') 速度。使用 Cox 回归模型，将年龄、性别和基线调整的精神压力引起的 MAV 测量值作为先验定义的复合事件术语的预测因子进行检查，复合事件术语包括全因死亡率和/或非致命性心血管事件，导致计划外住院（主要不良心血管事件 [MACE]）。中位随访时间为 4 年。样本主要为男性、白人，纽约心脏协会功能等级为 I 级，平均年龄为 63 +/- 10.2 岁。 MS 引起的 e'（风险比 [HR] = .73）和 s'（HR = .73）变化显着（p
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annular velocity (MAV) and cardiovascular outcome in patients with CAD. MAV, specifically, diastolic early (e'), diastolic late (a'), and systolic (s') velocities were obtained at rest and during mental stress testing in 224 patients with clinically stable CAD. Using Cox regression models, age, sex, and baseline-adjusted mental stress-induced MAV measures were examined as predictors of a priori defined composite event term that comprised all-cause mortality and/or nonfatal cardiovascular events, resulting in an unplanned hospitalization (major adverse cardiovascular events [MACE]). Median follow-up was 4 years. The sample was predominantly male, Caucasian with New York Heart Association functional class I and a mean age of 63 +/- 10.2 years. MS-induced changes in e' (hazard ratio [HR] = .73) and s' (HR = .73) were significant (p