IgM MGUS ANTI-MAG NEUROPATHY WITH PREDOMINANT MUSCLE WEAKNESS AND EXTENSIVE MUSCLE ATROPHY
IgM MGUS ANTI-MAG NEUROPATHY WITH PREDOMINANT MUSCLE WEAKNESS AND EXTENSIVE MUSCLE ATROPHY
复制标题
DOI：
10.1002/mus.21741
复制
发表时间：
2010-09-01
期刊：
影响因子：
3.4
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Kawagashira, Yuichi;Kondo, Naohide;Sobue, Gen
我们报告一位抗髓鞘相关糖蛋白（MAG）神经病变的病人，主要表现为严重的运动症状，伴随着广泛的肌肉萎缩模仿腓骨肌萎缩症。神经传导检查显示运动传导速度轻度减慢，远端潜伏期显著延长。腓肠神经活检显示广泛分布的髓鞘和阳性染色的有髓纤维与IgM抗体。以肌肉萎缩为主的运动症状可能是抗MAG神经病的临床表现之一。肌肉神经42：433-435，2010
We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti-MAG neuropathy. Muscle Nerve 42: 433-435, 2010