Direct assembly of nucleoside precursors from two- and three-carbon units
Direct assembly of nucleoside precursors from two- and three-carbon units
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DOI：
10.1002/anie.200601267
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Sutherland, John D.
中科院分区：
文献类型：
--
作者：
Anastasi, Carole;Crowe, Michael A.;Sutherland, John D.
甜味和生命：戊糖氨基恶唑啉-潜在的益生元核苷合成的中间体-可以在水中通过绕过相应的糖的反应产生。2-氨基恶唑是乙醇醛和氨腈的缩合产物，在温和条件下与甘油醛反应，反应过程基本上是定量的，对核糖和阿拉伯糖氨基恶唑啉具有高度立体选择性。© 2006 Wiley-VCH Verlag GmbH & Co. KGaA。
(Chemical Equation Presented) Sweetness and life: Pentose aminooxazolines-intermediates in potentially prebiotic nucleoside synthesis-can be produced in water from a reaction that bypasses the corresponding sugar. 2-Aminooxazole, a condensation product of glycolaldehyde and cyanamide, reacts with glyceraldehyde under mild conditions in a remarkable process that is essentially quantitative, and is highly stereoselective for ribose and arabinose aminooxazolines.© 2006 Wiley-VCH Verlag GmbH & Co. KGaA.