FOXP3 expression and clinical characteristics of hepatocellular carcinoma
FOXP3 expression and clinical characteristics of hepatocellular carcinoma
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FOXP3在肝细胞癌中的表达及临床特征
DOI：
10.3748/wjg.v16.i43.5502
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发表时间：
2010-11-21
影响因子：
4.3
通讯作者：
Zhang, Ying-Qi
中科院分区：
文献类型：
--
作者：
Wang, Wei-Hua;Jiang, Chang-Li;Zhang, Ying-Qi
目的：目的：研究转录因子叉头盒蛋白3（FOXP3）在肝细胞癌（HCC）中的生物学特性和临床意义。分析FOXP3染色与肝癌临床危险因素的关系，探讨FOXP3在肝癌中的临床特征。结果：部分肝癌细胞系中存在FOXP3的mRNA和蛋白表达。免疫组化（IHC）分析显示，48%的HCC显示FOXP3染色，但我们没有发现任何FOXP3染色在正常肝组织和癌旁组织。免疫组化和共聚焦显微镜分析显示FOXP3主要表达于肿瘤细胞的胞核和胞浆。在HCC中，FOXP 3的分布与肝硬化相似，但与B型肝炎病毒不同。结论：FOXP3在HCC中的表达特点值得进一步研究，以探讨其在肝硬化和HCC发生发展中的作用。(C)2010年百世登。All rights reserved.
AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC).METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessed to identify the clinical characteristics of FOXP3 in HCC.RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC.CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC. (C) 2010 Baishideng. All rights reserved.