Haloperidol decreases hyperkinetic paw treading induced by globus pallidus lesions in the rat.
Haloperidol decreases hyperkinetic paw treading induced by globus pallidus lesions in the rat.
复制标题
氟哌啶醇可减少大鼠苍白球病变引起的多动爪踩踏。
DOI：
10.1006/exnr.1997.6472
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Berridge,KC
中科院分区：
文献类型：
--
作者：
Cromwell,HC;Berridge,KC
全身性氟哌啶醇注射可降低由基底神经节损伤引起的几种多动综合征的严重程度。先前已报告大鼠运动过度模型，即由口腔感觉刺激引发的过度足踏，是由苍白球或腹侧苍白球/无名质病变引起的。这种运动过度表现为前爪和前肢的伸展和收缩，可以剧烈地重复发出，每次长达几分钟。本研究的目的是发现这种实验性运动过度是否与人类运动过度综合征非常相似：它是否可以被精神抑制剂抑制？对苍白球病变后表现出足踏综合征的大鼠全身注射氟哌啶醇（2 mg/kg）、地西泮（5 mg/kg，作为镇静剂对照）或溶剂。对多动性踩踏和感觉运动功能测试的影响进行了比较。结果表明，氟哌啶醇对双侧苍白球毁损大鼠的运动功能亢进有改善作用，但对腹侧苍白球/无名质毁损大鼠的运动功能亢进无改善作用。相比之下，安定，产生镇静和感觉运动障碍，并没有减少由任何病变引起的运动过度。虽然只有氟哌啶醇减少苍白球病变后的多动性踩踏，氟哌啶醇产生的感觉运动障碍比地西泮攀爬，悬挂，翻正反射测试。这些结果暗示了多巴胺神经传递在苍白球病变诱导的触发性运动过度踩踏的表达中的特定作用。
Systemic haloperidol injections decrease the severity of several hyperkinetic syndromes caused by damage to the basal ganglia in humans. A model of hyperkinesia in the rat, exaggerated paw treading triggered by oral sensory stimulation, has been reported previously to result from lesions of the globus pallidus or ventral pallidum/substantia innominata. This hyperkinesia appears as forepaw and forelimb extension and retraction, which can be emitted vigorously and repeatedly for up to minutes at a time. The present study aimed to discover whether this experimental hyperkinesia is pharmacologically similar to human hyperkinetic syndromes: can it be suppressed by neuroleptic administration? Systemic injections of haloperidol (2 mg/kg), diazepam (5 mg/kg, as a sedative comparison), or vehicle were given to rats that expressed the paw treading syndrome after pallidal lesions. Effects on hyperkinetic treading and on tests of sensorimotor function were compared. Results indicated that haloperidol was effective in ameliorating the hyperkinesia in rats with bilateral globus pallidus lesions but not in rats with ventral pallidum/substantia innominata lesions. By contrast, diazepam, which produced sedation and sensorimotor impairment, did not decrease the hyperkinesia induced by either lesion. Although only haloperidol decreased hyperkinetic treading after globus pallidus lesions, haloperidol produced less of a sensorimotor impairment than diazepam on climbing, hanging, and righting reflex tests. These results implicate a specific role for dopamine neurotransmission in the expression of triggered hyperkinetic treading induced by globus pallidus lesions.