Rhodium-catalyzed Synthesis of 1-Arylisoquinoline Derivatives through Annulative Coupling of 3-Aryl-1,2-benzisoxazoles and Alkynes
Rhodium-catalyzed Synthesis of 1-Arylisoquinoline Derivatives through Annulative Coupling of 3-Aryl-1,2-benzisoxazoles and Alkynes
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DOI：
10.1246/cl.170618
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发表时间：
2017-07
影响因子：
1.6
通讯作者：
Teppei Noguchi;Yuji Nishii;M. Miura
中科院分区：
文献类型：
--
作者：
Teppei Noguchi;Yuji Nishii;M. Miura
在Cp*Rh（III）催化剂存在下，3-芳基-1，2-苯并异恶唑和炔的直接成环偶联有效地进行，以产生在药物化学以及材料化学中感兴趣的2-（1-异喹啉基）苯酚。产物也可以是喹啉基双齿配体的有用前体。
Direct annulative coupling of 3-aryl-1,2-benzisoxazoles and alkynes efficiently proceeds in the presence of a Cp*Rh(III) catalyst to produce 2-(1-isoquinolinyl)phenols of interest in medicinal chemistry as well as materials chemistry. The products may also be useful precursors of quinoline-based bidentate ligands.