PIM kinases: an overview in tumors and recent advances in pancreatic cancer.
PIM kinases: an overview in tumors and recent advances in pancreatic cancer.
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DOI：
10.2217/fon.13.229
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发表时间：
2014-05
期刊：
影响因子：
3.3
通讯作者：
Jian-wei Xu;Taiping Zhang;Tian-xiao Wang;L. You;Yupei Zhao
中科院分区：
文献类型：
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作者：
Jian-wei Xu;Taiping Zhang;Tian-xiao Wang;L. You;Yupei Zhao
PIM激酶代表丝氨酸/苏氨酸激酶家族，其由三个不同的成员（PIM 1、PIM 2和PIM 3）组成。在包括胰腺癌在内的多种肿瘤中观察到PIM激酶的异常表达。PIM激酶在细胞周期调控、细胞凋亡、干细胞特性、代谢、自噬、耐药性和靶向治疗等方面发挥着重要作用。PIM激酶在胰腺癌中的作用包括调节细胞增殖、凋亡、细胞周期、形成、血管生成和预测预后。阻断PIM激酶的活性可以防止胰腺癌的发展。PIM激酶可能成为肿瘤治疗的新靶点。
The PIM kinases represent a family of serine/threonine kinases, which is composed of three different members (PIM1, PIM2 and PIM3). Aberrant expression of PIM kinases is observed in variety of tumors, including pancreatic cancer. The PIM kinases play pivotal roles in the regulation of cell cycle, apoptosis, properties of stem cells, metabolism, autophagy, drug resistance and targeted therapy. The roles of PIM kinases in pancreatic cancer include the regulation of proliferation, apoptosis, cell cycle, formation, angiogenesis and prediction prognosis. Blocking the activities of PIM kinases could prevent pancreatic cancer development. PIM kinases may be a novel target for cancer therapy.