PSYCHOPHYSICAL EXAMINATION OF PAIN INDUCED BY DEFINED CO2 PULSES APPLIED TO THE NASAL-MUCOSA
PSYCHOPHYSICAL EXAMINATION OF PAIN INDUCED BY DEFINED CO2 PULSES APPLIED TO THE NASAL-MUCOSA
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DOI：
10.1016/0304-3959(92)90187-g
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发表时间：
1992-04-01
期刊：
影响因子：
7.4
通讯作者：
HANDWERKER, HO
中科院分区：
文献类型：
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作者：
ANTON, F;EUCHNER, I;HANDWERKER, HO
在 12 名志愿者受试者中，通过向鼻粘膜施加精确控制的二氧化碳脉冲来进行有毒化学刺激。每个受试者参加 2 次相同的心理物理学课程，包括：(1) 确定疼痛阈值，(2) 确定对固定浓度的不同持续时间的 CO2 脉冲的刺激响应函数，以及 (3) 确定对不同浓度的 CO2 的刺激响应函数。在此测试中，我们还检查了视觉模拟量表 (VAS) 和震级估计 (ME) 程序的相对灵敏度。通过比较两次会议中获得的结果来测试心理物理数据的可靠性。疼痛阈值的个体差异相当低。使用的所有 CO2 脉冲宽度都会诱发阶段性疼痛感觉，平均编码刺激持续时间长达 1 秒。较长的使用时间并没有进一步增加疼痛感。对不同浓度CO2的刺激反应函数可以用史蒂文斯幂函数很好地描述。在我们手中，VAS 和 ME 程序被证明同样敏感。获得的心理物理学数据似乎相当可靠，因为在两次会议中获得的评级没有观察到显着差异。
In 12 volunteer subjects, noxious chemical stimulation was performed by applying precisely controlled CO2 pulses to the nasal mucosa. Each subject participated in 2 identical psychophysical sessions including: (1) determination of the pain threshold, (2) determination of stimulus response functions to different durations of CO2 pulses with fixed concentration and (3) determination of stimulus response functions to different concentrations of CO2. In this test we also examined the relative sensitivity of the visual analogue scale (VAS) and the magnitude estimation (ME) procedure. The reliability of the psychophysical data was tested by comparing the results obtained in both sessions. The intra-individual variability of the pain threshold was rather low. All the CO2 pulse widths used induced phasic pain sensations which when averaged encoded stimulus durations of up to 1 sec. Longer application periods did not further increase the pain sensations. The stimulus response functions to different concentrations of CO2 could be described well with Stevens' power functions. In our hands the VAS and ME procedures proved to be equally sensitive. The obtained psychophysical data appeared to be rather reliable since no significant differences in the ratings obtained in both sessions could be observed.