The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers
The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers
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DOI：
10.1007/s002130051057
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发表时间：
1999-08-01
影响因子：
3.4
通讯作者：
Cowen, PJ
中科院分区：
文献类型：
--
作者：
Young, AH;Sahakian, BJ;Cowen, PJ
基本原理：皮质类固醇在某些神经精神疾病中升高，这可能导致这些疾病中报告的神经心理障碍。目的：探讨氢化可的松对学习记忆和执行功能的影响。研究方法：在随机、安慰剂对照、交叉、受试者内设计中，对正常男性志愿者给予氢化可的松20 mg，每日两次，持续10天。学习、记忆和执行功能采用剑桥神经心理学自动成套测验中选定的子测验进行测量。结果：氢化可的松可引起大鼠视觉空间记忆障碍。这些包括增加搜索错误和受损的空间工作记忆子测试中的策略的使用，此外，氢化可的松的管理与配对联想学习子测试中更多的错误，虽然没有效果被发现在伦敦塔。氢化可的松在某些测试（模式和空间识别记忆）中加速反应。结论：这些结果表明，氢化可的松的长期管理导致赤字在某些测试的认知功能额叶功能障碍敏感，并可能有助于在某些神经精神疾病的认知障碍。
Rationale: Corticosteroids are elevated in certain neuropsychiatric disorders and this may contribute to the neuropsychological impairments reported in these disorders. Objective: To examine the effects of hydrocortisone on learning, memory and executive function. Methods: Hydrocortisone 20 mg was administered twice daily for 10 days to normal male volunteers in a randomized, placebo control, crossover, within-subject design. Learning, memory and executive function were measured using selected subtests from the Cambridge Neuropsychological Test Automated Battery. Results: Hydrocortisone caused impairments of visuo-spatial memory. These included increased within search errors and impaired use of strategies on the spatial working memory subtest, In addition, administration of hydrocortisone was associated with more errors in the paired associate learning subtest, although no effect was found on the Tower of London. Hydrocortisone speeded response latencies in certain tests (pattern and spatial recognition memory). Conclusion: These results indicate that chronic administration of hydrocortisone leads to deficits in certain tests of cognitive function sensitive to frontal lobe dysfunction and may contribute to the cognitive impairment reported in certain neuropsychiatric disorders.