QUANTITATIVE-ANALYSIS OF TRABECULAR BONE-STRUCTURE
QUANTITATIVE-ANALYSIS OF TRABECULAR BONE-STRUCTURE
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DOI：
10.1016/8756-3282(93)90139-2
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发表时间：
1993-05-01
期刊：
影响因子：
4.1
通讯作者：
YAMAGUCHI, K
中科院分区：
文献类型：
--
作者：
COMPSTON, JE;GARRAHAN, NJ;YAMAGUCHI, K
骨小梁结构是骨强度的重要决定因素，并与治疗干预在骨质疏松疾病状态下恢复骨结构的潜力相关。近年来，随着骨结构定量评估新技术的发展及其在骨质疏松症治疗和治疗中的应用，重新唤醒了人们对这一课题的兴趣。在微观解剖水平上，骨丢失存在两种机制：骨小梁变薄和骨小梁穿透和侵蚀；这些机制反过来又依赖于骨重建的潜在变化。骨小梁变薄主要与细胞水平的低周转状态和骨形成减少有关，而高周转状态，无论有没有吸收深度的增加，都容易导致小梁穿透和丢失。后一种过程导致骨小梁结构的比例更大的破坏，但这两种机制在某种程度上是相互依赖的，骨小梁变薄最终导致正常深度的吸收腔穿透小梁(Compston等人)。(1989年)。虽然一些药物，如氟化钠和甲状旁腺激素肽，增加骨小梁厚度的能力已经得到很好的证实(Briancon&Meunier 1981)，但目前使用的治疗方案恢复受损的小梁结构的潜力仍未得到证实。
Trabecular bone structure is an important determinant of bone strength and has implications relevant to the potential of therapeutic interventions to restore bone architecture in osteoporotic disease states. Over recent years interest in this topic has been reawakened by the development of new techniques for the quantitative assessment of bone structure and their application to untreated and treated osteoporosis.At the microanatomic level two mechanisms of bone loss exist, trabecular thinning and penetration through and erosion of trabeculae; these in turn are dependent on the underlying changes in bone remodelling. Trabecular thinning is predominantly associated with low turnover states and reduced bone formation at the cellular level whilst high turnover states, with or without an increase in resorption depth, predispose to trabecular penetration and loss. The latter process leads to proportionately greater disruption of trabecular structure but the two mechanisms are to some extent interdependent, trabecular thinning eventually leading to penetration of trabeculae by resorption cavities of normal depth (Compston et al. 1989). Whilst the ability of some drugs, for example sodium fluoride and parathyroid hormone peptide, to increase trabecular thickness is well established (Briancon & Meunier 1981) the potential of currently used therapeutic regimes to restore disrupted trabecular architecture remains unproven.