Anti-tubulin autoantibodies in acquired demyelinating polyneuropathies.
Anti-tubulin autoantibodies in acquired demyelinating polyneuropathies.
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DOI：
10.1086/513801
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发表时间：
1997-12
期刊：
影响因子：
--
通讯作者：
A. Connolly;A. Pestronk
中科院分区：
文献类型：
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作者：
A. Connolly;A. Pestronk
选择性高滴度抗微管蛋白自身抗体与格林-巴利综合征和慢性炎症性脱髓鞘性多发性神经病（CIDP）相关。低滴度抗微管蛋白自身抗体是一些人血清的正常成分。用单克隆抗微管蛋白自身抗体对7份人血清的分析表明，这些抗体识别的表位位于微管蛋白的中心保守区域内。来自3名IgM单克隆抗体和CIDP患者的血清与跨越β-微管蛋白的aa 301-314的表位反应，该表位与几种人病毒具有一定的序列同源性。天然多克隆抗微管蛋白抗体也结合微管蛋白的中心区域。相反，在小鼠中诱导的多克隆微管蛋白抗体与氨基或羧基末端上的表位反应。在约一半的CIDP患者中发现了对其他神经抗原具有低反应性的选择性多克隆抗微管蛋白自身抗体。
Selective high-titer anti-tubulin autoantibodies are associated with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP). Low-titer anti-tubulin autoantibodies are a normal component of some human sera. Analysis of 7 human sera with monoclonal anti-tubulin autoantibodies showed that the epitopes recognized by these antibodies are within central, conserved regions of tubulin. Sera from 3 patients with IgM monoclonal antibodies and CIDP reacted to an epitope spanning aa 301-314 of beta-tubulin, which has some sequence homology to several human viruses. Natural polyclonal anti-tubulin antibodies also bind to central regions of tubulin. In contrast, polyclonal tubulin antibodies induced in mice react to epitopes on the amino- or carboxy-terminal. Selective polyclonal anti-tubulin autoantibodies with low reactivity to other neural antigens are found in about one-half of patients with CIDP.