Increased inflammatory markers are associated with early periventricular leukomalacia
Increased inflammatory markers are associated with early periventricular leukomalacia
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DOI：
10.1111/j.1469-8749.2007.00587.x
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发表时间：
2007-08
影响因子：
3.8
通讯作者：
K. Tsukimori;H. Komatsu;Takazumi Yoshimura;S. Hikino;T. Hara;N. Wake;H. Nakano
中科院分区：
文献类型：
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作者：
K. Tsukimori;H. Komatsu;Takazumi Yoshimura;S. Hikino;T. Hara;N. Wake;H. Nakano
本研究的目的是调查炎症标志物是否与脑室周围白质软化（PVL）的发生有关。研究了脐血中性粒细胞超氧化物（O2-）产生和血浆抗氧化超氧化物歧化酶（SOD）活性。参与者是患有早期PVL的早产儿（n=6; 3例男性，3例女性;平均出生体重1458 g [SD 517]，范围620- 2040 g;平均胎龄29.8周[SD 2.9]，范围27- 34周）;和无PVL的早产对照婴儿（n=10; 5例男性，5例女性;平均出生体重1838 g [SD 664]，范围925- 2748 g;平均胎龄30.6周[SD 3.1]，范围26- 34周）。此外，还测量了脐带血中的促炎细胞因子水平。N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸诱导的早期PVL婴儿中性粒细胞产生的O2-显著高于对照组。相反，各组之间铜/锌-SOD浓度和SOD活性无显著差异。早期PVL婴儿的白细胞介素（IL）-1 β和肿瘤坏死因子-α（但不是IL-6、IL-8或粒细胞集落刺激因子）浓度显著高于对照婴儿。活化的中性粒细胞产生的过量O2和促炎细胞因子产生增加可能在导致PVL中白色物质损伤的分子级联中发挥作用。
The aim of the study was to investigate whether inflammatory markers are associated with the occurrence of periventricular leukomalacia (PVL). Superoxide (O2‐) production of neutrophils and plasma antioxidative superoxide dismutase (SOD) activity in umbilical cord blood were studied. Participants were preterm infants with early PVL (n=6; three males, three females; mean birthweight 1458g [SD 517], range 620–2040g; mean gestational age 29.8wks [SD 2.9], range 27–34wks); and preterm control infants without PVL (n=10; five males, five females; mean birthweight 1838g [SD 664], range 925–2748g; mean gestational age 30.6wks [SD 3.1], range 26–34wks). In addition, pro‐inflammatory cytokine levels were measured in the umbilical cord blood. N‐formyl‐methionyl‐leucyl‐phenylalanine‐induced O2‐ production by neutrophils in infants with early PVL was significantly higher than that in the control group. In contrast, there was no significant difference in concentrations of copper/zinc‐SOD and SOD activity between groups. Concentrations of interleukin (IL)‐1β and tumour necrosis factor‐α (but not IL‐6, IL‐8, or granulocyte‐colony stimulating factor) were significantly higher in infants with early PVL than in control infants. The excess O2‐ produced by activated neutrophils with increased pro‐inflammatory cytokine production could play a role in the molecular cascade leading to white matter damage in PVL.