Neuropsychological evidence for a topographical learning mechanism in parahippocampal cortex
Neuropsychological evidence for a topographical learning mechanism in parahippocampal cortex
复制标题
DOI：
10.1080/02643290125929
复制
发表时间：
2001-09-01
影响因子：
3.4
通讯作者：
Kanwisher, N
中科院分区：
文献类型：
--
作者：
Epstein, R;DeYoe, EA;Kanwisher, N
海马旁位置区（PPA; Epstein & Kanwisher，1998）是后海马旁皮质内的区域，其选择性地响应传达关于局部空间布局的信息的视觉刺激。在这里，我们描述了两个病人谁遭受损害后，PPA血管事件。两人随后表现出地形材料的记忆问题，并无法在陌生的环境中独立导航。连续n-回视觉记忆测试的性能显着低于新的场景样刺激比新的物体样刺激。与此相反，性能是正常的一个著名的地标识别任务和两个感知任务，需要在线分析场景几何。这两名患者都能够制作出发病前学习过的地方的准确地图，但无法制作出新地方的准确地图。这些结果与之前的神经影像学研究结果相吻合，证明PPA（1）选择性地参与处理有关周围空间几何形状的信息，（2）在将这些信息编码到记忆中时，可能比在最初的感知处理、识别或回忆这些信息时发挥更关键的作用。
The Parahippocampal Place Area (PPA; Epstein & Kanwisher, 1998) is a region within posterior parahippocampal cortex that responds selectively to visual stimuli that convey information about the layout of local space. Here we describe two patients who suffered damage to the PPA after vascular incidents. Both subsequently exhibited memory problems for topographical materials and were unable to navigate unassisted in unfamiliar environments. Performance on a continuous n-back visual memory test was significantly lower for novel scene-like stimuli than for novel object-like stimuli. In contrast, performance was normal on a famous landmark recognition task and on two perceptual tasks that required on-line analysis of scene geometry. Both patients were able to produce accurate maps of premorbidly learned places but were unable to produce accurate maps of new places. These results converge with previous neuroimaging work to demonstrate that the PPA (1) is selectively involved in processing information about the geometry of surrounding space, and (2) may play a more critical role in the encoding of this information into memory than in the initial perceptual processing, recognition, or recall of this information.