The prognostic role of a gene signature from tumorigenic breast-cancer cells.
The prognostic role of a gene signature from tumorigenic breast-cancer cells.
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DOI：
10.1056/nejmoa063994
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发表时间：
2007-01-18
影响因子：
158.5
通讯作者：
Clarke, Michael F.
中科院分区：
文献类型：
--
作者：
Liu, Rui;Wang, Xinhao;Clarke, Michael F.
背景：乳腺癌中含有少数表达CD 44但CD 24（CD 44 + CD 24-/low）水平较低或检测不到的癌细胞，这些癌细胞具有比其他亚型癌细胞更高的致瘤能力。差异表达基因被用来产生一个186个基因的"侵袭性“基因标签（IGS），评估其与乳腺癌或其他类型癌症患者的总生存期和无转移生存期的相关性。结果：IGS与总生存期和无转移生存期之间存在显著相关性（P
BACKGROUND:Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes of cancer cells.METHODS:We compared the gene-expression profile of CD44+CD24-/low tumorigenic breast-cancer cells with that of normal breast epithelium. Differentially expressed genes were used to generate a 186-gene ``invasiveness'' gene signature (IGS), which was evaluated for its association with overall survival and metastasis-free survival in patients with breast cancer or other types of cancer.RESULTS:There was a significant association between the IGS and both overall and metastasis-free survival (P