Effect of Dialysis on Antiplatelet Drug Efficacy in Uremic Patients with Coronary Heart Disease.
Effect of Dialysis on Antiplatelet Drug Efficacy in Uremic Patients with Coronary Heart Disease.
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透析对尿毒症合并冠心病患者抗血小板药物疗效的影响
DOI：
10.4103/0366-6999.211888
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发表时间：
2017-08-20
影响因子：
6.1
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Fu DL;Zhao TT;Peng WH;Yang P;Liu XF;Zhang H;Li XL;Wang Y;Zheng JG;Gao YX;Lu HK;Wang Q
背景：冠状动脉介入治疗是尿毒症合并冠心病患者的主要治疗手段。关于透析是否降低双联抗血小板药物疗效的研究有限。本研究的目的是检查透析对冠心病尿毒症患者抗血小板药物的影响。研究方法：本研究纳入了2015年11月至2017年5月在中日友谊医院接受经皮冠状动脉介入治疗的26例尿毒症患者。我们检查了血液透析前后的血栓弹力图结果。采用自身配对t检验分析血小板聚集抑制率的变化。结果如下：血透前后花生四烯酸诱导的血小板聚集抑制率分别为82.56 ± 2.79%和86.42 ± 3.32%（t =-1.278，P = 0.213）。血液透析前后二磷酸腺苷诱导的血小板聚集抑制率分别为67.87 ± 5.10%和61.94 ± 5.90%（t = 1.425，P = 0.167）。血液透析前后血小板聚集抑制率差异无统计学意义。这些结果也适用于对阿司匹林和氯吡格雷敏感性不同的患者。结论：透析不影响阿司匹林和氯吡格雷对尿毒症合并冠心病患者的抗血小板作用。
Background: Coronary intervention therapy is the main treatment for uremic patients with coronary heart disease. The studies on whether dialysis reduces the efficacy of dual antiplatelet drugs are limited. The aim of this study was to examine the effect of dialysis on antiplatelet drugs in uremic patients with coronary heart disease. Methods: This study included 26 uremic patients who had undergone percutaneous coronary intervention in China-Japan Friendship Hospital from November 2015 to May 2017. We examined their thromboelastography results before and after hemodialysis. Self-paired t-tests were employed to analyze changes in the inhibition rate of platelet aggregation. Results: The mean inhibition rates of arachidonic acid-induced platelet aggregation before and after hemodialysis were 82.56 ± 2.79% and 86.42 ± 3.32%, respectively (t = −1.278, P = 0.213). The mean inhibition rates of adenosine diphosphate-induced platelet aggregation before and after hemodialysis were 67.87 ± 5.10% and 61.94 ± 5.90%, respectively (t = 1.425, P = 0.167). There was no significant difference in the inhibition rates of platelet aggregation before or after hemodialysis. These results also applied to patients with different sensitivity to aspirin and clopidogrel. Conclusion: Dialysis did not affect the antiplatelet effects of aspirin and clopidogrel in uremic patients with coronary heart disease.
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影响因子：
1.6
作者：
Li M;Wang H;Xuan L;Shi X;Zhou T;Zhang N;Huang Y
通讯作者：
Huang Y
两种用于评估接受经皮冠状动脉介入治疗的中国急性心肌梗死患者氯吡格雷血小板反应性的即时血小板功能测试的头对头比较
影响因子：
6.1
作者：
Yao Y;Zhang JH;Tang XF;He C;Ma YL;Xu JJ;Song Y;Liu R;Meng XM;Song L;Wang M;Gao RL;Yuan JQ
通讯作者：
Yuan JQ
影响因子：
3.4
作者：
Mrdovic, Igor;Colic, Mirko;Marinkovic, Jelena
通讯作者：
Marinkovic, Jelena
影响因子：
6.1
作者：
Li H;Feng SJ;Su LL;Wang W;Zhang XD;Wang SX
通讯作者：
Wang SX
影响因子：
20.1
作者：
Bhatt, Deepak L.;Hulot, Jean-Sebastien;Harrington, Robert A.
通讯作者：
Harrington, Robert A.