Functional Effects of a Retained Ancestral Polymorphism in Prestin
Functional Effects of a Retained Ancestral Polymorphism in Prestin
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prestin 中保留的祖先多态性的功能效应
DOI：
10.1093/molbev/msw222
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发表时间：
2017-01-01
影响因子：
10.7
通讯作者：
Shi, Peng
中科院分区：
文献类型：
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作者：
Li, Yuan-Yuan;Liu, Zhen;Shi, Peng
分子基型词素回声定位已引起很多关注。关于蝙蝠和齿鲸之间普雷斯汀序列平行演变的最新发现表明，在回声分配的演变演变过程中，发生了高频听力的适应。在这里，我们报告说，尽管用于与频率调制（FM）扫描发射回声定位调用的蝙蝠的物种树是销食的，但普雷斯汀在FM蝙蝠之间表现出相似的功能变化。定点诱变表明，FM蝙蝠中的氨基酸308s造成了Prestin的类似功能变化。我们强烈支持，位置308处的丝氨酸的发生是祖先多态性不完全的谱系排序引起的偏瘫情况。我们的研究不仅揭示了蝙蝠中回声分配的复杂分子基础，而且还要求谨慎地推断出经历快速辐射的物种中分子收敛的推断。
Molecular basis formammalian echolocation has been receiving much concerns. Recent findings on the parallel evolution of prestin sequences among echolocating bats and toothed whales suggest that adaptations for high-frequency hearing have occurred during the evolution of echolocation. Here, we report that although the species tree for echolocating bats emitting echolocation calls with frequency modulated (FM) sweeps is paraphyletic, prestin exhibits similar functional changes between FM bats. Site-directed mutagenesis shows that the amino acid 308S in FM bats is responsible for the similar functional changes of prestin. We strongly support that the occurrence of serine at position 308 is a case of hemiplasy, caused by incomplete lineage sorting of an ancestral polymorphism. Our study not only reveals sophisticated molecular basis of echolocation in bats, but also calls for caution in the inference of molecular convergence in species experiencing rapid radiation.