Phase angle from bioelectrical impedance analysis:: Population reference values by age, sex, and body mass index
Phase angle from bioelectrical impedance analysis:: Population reference values by age, sex, and body mass index
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DOI：
10.1177/0148607106030004309
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Mueller, Manfred J.
中科院分区：
文献类型：
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作者：
Bosy-Westphal, Anja;Danielzik, Sandra;Mueller, Manfred J.
背景：生物电阻抗相角的使用已被推荐为临床环境中的一种预后工具，但已发表的参考数据库存在差异和不完整。(例如，他们没有考虑身体质量指数[BMI]，而且缺乏针对儿童的数据)。方法：在德国一个大型数据库中生成按年龄、性别和BMI分层的相角参考值，包括15,605名儿童和青少年和214,732名成年人，并对相角值的决定因素进行评估。这些参考值被应用于3组患者，并与之前发表的美国和瑞士的参考值进行了比较。结果：性别和年龄是影响成人相位角的主要因素，男性和年轻受试者的相位角较高。在儿童和青少年中，年龄和BMI是相角的主要决定因素。在正常和超重的成年人中，相角随着BMI的增加而增加，但在BMI>；40 kg/m(2)时，相角与BMI成反比。在肝硬变患者中，低相角的患病率随病情的加重而增加，而代谢综合征患者与对照组之间无明显差异。不同人群的相角参考值存在较大差异。这些差异不能用年龄或BMI来解释，可能是由于阻抗分析仪之间的差异。结论：成人和儿童的相位角决定因素不同。在成人中，BMI对相角的影响取决于BMI的范围。在不同的临床情况下，相角的预后价值可能不同。建议使用特定于总体的参考值，也可能使用特定于阻抗分析仪的相角参考值。
Background: The use of bioelectrical impedance phase angle has been recommended as a prognostic tool in the clinical setting, but published reference data bases are discrepant and incomplete. (eg, they do not consider body mass index [BMI], and data are lacking for children). Methods: Phase angle reference values stratified by age, sex, and BMI were generated in a large German data base of 15,605 children and adolescents and 214,732 adults, and the determinants of phase angle values were assessed. The reference values were applied to 3 groups of patients and compared with previously published reference values from the United States and Switzerland. Results: Gender and age were the main determinants of phase angle in adults, with men and younger subjects having higher phase angles. In children and adolescents, age and BMI were the main determinants of phase angle. In normal and overweight adults, phase angle increased with increasing BMI, but there was an inverse association at a BMI > 40 kg/m(2). In cirrhosis, the prevalence of a low phase angle increased with the state of disease, whereas it was not different between patients with the metabolic syndrome and controls. There are considerable differences between phase angle reference values from different populations. These differences are not explained by age or BMI and may be due to differences between impedance analyzers. Conclusion: The determinants of phase angle differ between adults and children. In adults, the influence of BMI on phase angle depended on the BMI range. The prognostic value of phase angle may differ in different clinical settings. The use of population-specific and probably impedance-analyzer-specific reference values for phase angle is recommended.