The biologic importance of tumor-infiltrating lymphocytes.
The biologic importance of tumor-infiltrating lymphocytes.
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DOI：
10.1111/j.1600-0560.2010.01506.x
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发表时间：
2010-04
影响因子：
1.7
通讯作者：
Dranoff G
中科院分区：
文献类型：
--
作者：
Hodi FS;Dranoff G
详细的病理学分析已经描绘了肿瘤内CD 8+细胞毒性T细胞与各种癌症的有利临床结果之间的密切关联。相反，在肿瘤部位存在负性免疫调节元件，如FoxP 3 + T细胞（T细胞）和PD-1/PD-L1共刺激分子，与较差的患者存活率密切相关。总之，这些结果表明肿瘤微环境中细胞毒性和调节途径之间的平衡作为预后的关键决定因素的重要性。该免疫指数还为设计治疗策略以扩大抗肿瘤细胞毒性T细胞的群体和减弱免疫调节提供了框架。在这些方法中，用经照射的自体肿瘤细胞接种疫苗，所述自体肿瘤细胞经工程改造以分泌粒细胞-巨噬细胞集落刺激因子（GM-CSF），然后通过细胞毒性T淋巴细胞相关抗原-4（CTLA-4）的抗体阻断，为一些晚期黑素瘤患者提供了临床益处。治疗后活检中肿瘤坏死的程度与CD 8 + T细胞与FoxP 3 + T细胞比率的自然对数线性相关。这些发现揭示了内源性和治疗诱导反应中肿瘤保护的免疫特征之间的一致性，强烈支持Martin Mihm的原始见解。
Detailed pathologic analysis has delineated a close association between intra-tumoral CD8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP3+ T cells (Tregs) and PD-1/PD-L1 co-stimulatory molecules, is closely associated with inferior patient survival. Together, these results indicate the importance of the balance between cytotoxic and regulatory pathways in the tumor microenvironment as a critical determinant of prognosis. This immune index also provides a framework for devising therapeutic strategies to enlarge the population of anti-tumor cytotoxic T cells and attenuate immune regulation. Among these approaches, vaccination with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF) followed by antibody blockade of cytotoxic T lymphocyte associated antigen-4 (CTLA-4) provides clinical benefits for some advanced-course melanoma patients. The extent of tumor necrosis in post-treatment biopsies is linearly related to the natural logarithm of the ratio of CD8+ T cells to FoxP3+ Tregs. These findings reveal a concordance between the immune signature of tumor protection in endogenous and therapy-induced responses, strongly supporting Martin Mihm’s original insights.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
15.3
作者：
Apostolou, I;von Boehmer, H
通讯作者：
von Boehmer, H
DOI：
10.1073/pnas.0408197102
发表时间：
2005-01-11
影响因子：
11.1
作者：
Chen, ML;Pittet, MJ;Khazaie, K
通讯作者：
Khazaie, K
PD-L1 的过度表达与人类肝细胞癌的肿瘤侵袭性和术后复发显着相关。
影响因子：
11.5
作者：
Gao, Qiang;Wang, Xiao-Ying;Fan, Jia
通讯作者：
Fan, Jia
影响因子：
10.3
作者：
CLARK, WH;ELDER, DE;HALPERN, AC
通讯作者：
HALPERN, AC