Effect of ventilation with soluble and diffusible gases on the size of air emboli.
Effect of ventilation with soluble and diffusible gases on the size of air emboli.
复制标题
可溶性和扩散性气体通气对空气栓塞大小的影响。
DOI：
10.1152/jappl.1991.70.3.1068
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
WagnerJr,WW
中科院分区：
文献类型：
--
作者：
PressonJr,RG;Kirk,KR;Haselby,KA;WagnerJr,WW
Pulmonary hypertension resulting from venous air embolism is known to increase after ventilation with highly soluble and diffusible gases. Exacerbation of the hypertension could be due to further blockage of the circulation if the bubbles enlarge as a result of ingress of gas by diffusion. This mechanism has been frequently cited but lacks direct proof. To determine directly whether intravascular air bubbles actually enlarge when highly soluble and diffusible gases are inspired, we used microscopy to measure the size of gas emboli in vivo. When air bubbles were injected into the right atrium, the bubbles that appeared in pulmonary arterioles were larger during ventilation with helium or nitrous oxide than with air. Air bubbles injected into the pulmonary artery enlarged when the inspired gas was changed to helium or nitrous oxide. The direction, magnitude, and timing of changes in bubble size were consistent with a net diffusion of gas into the bubbles. These data support the idea that venous air emboli enlarge during ventilation with soluble and diffusible gases and thereby cause further vascular obstruction.
