Mapping the relationship between anxiety, anhedonia, and depression.

Mapping the relationship between anxiety, anhedonia, and depression.
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DOI:
10.1016/j.jad.2017.06.006
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发表时间:
2017-10-15
影响因子:
6.6
通讯作者:
Kilgore J
Kilgore J
中科院分区:
医学2区
文献类型:
--
作者:
Winer ES;Bryant J;Bartoszek G;Rojas E;Nadorff MR;Kilgore J

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焦虑和抑郁通常是共病,但这种共病如何发展尚不确定。因此,在三项研究中,我们试图辨别快感缺乏是否可能是焦虑和抑郁之间的关键联系因素。三项研究询问了参与者的焦虑和抑郁症状:在研究1中,109名参与者完成了焦虑,抑郁,活动回避,以及避免活动的感知享受性和重要性的测量;在研究2中,747名参与者完成了快感缺乏,焦虑,抑郁和防御性的测量;在研究3中,216名参与者在四个时间点(跨度为11个月)完成了与研究2相同的结构评估。在研究1中,焦虑和抑郁的症状仅在那些由于与焦虑相关的回避而放弃潜在享受的个体中呈正相关;在研究2中,快感缺失的间接影响有助于解释焦虑症状如何将风险传递给抑郁症状;在研究3中,焦虑导致快感缺失,然后随着时间的推移抑郁,快感缺失导致焦虑,然后在5个月和11个月时抑郁。该手稿是有限的,在研究2中使用的学生样本,在研究1和2中的横截面方法,并依赖于自我评级的研究2和3。焦虑可能会通过快感缺失转变为抑郁,使得焦虑的人开始在引发焦虑的活动中失去乐趣,从而导致其他抑郁症状的发展。
Anxiety and depression are often comorbid conditions, but there is uncertainty as to how this comorbidity develops. Thus, in three studies, we attempted to discern whether anhedonia may be a key linking factor between anxiety and depression. Three studies asked participants about their symptoms of anxiety and depression: in Study 1, 109 participants completed measures of anxiety, depression, activity avoidance, and perceived enjoyability and importance of avoided activities; in Study 2, 747 participants completed measures of anhedonia, anxiety, depression, and defensiveness; in Study 3, 216 participants completed measures assessing the same constructs as in Study 2 at four time-points (ranging 11 months in span). In Study 1, symptoms of anxiety and depression were only positively related in individuals who relinquished potential enjoyment due to their anxiety-related avoidance; in Study 2, the indirect effect of anhedonia helped explained how anxiety symptoms imparted risk onto depressive symptoms; and in Study 3, anxiety led to anhedonia and then depression over time and anhedonia led to anxiety and then depression at both 5 and 11 months. The manuscript is limited by the use of a student sample in study 2, cross-sectional methods in studies 1 and 2, and reliance on self-ratings in studies 2 and 3. Anxiety may devolve into depression through anhedonia, such that anxious individuals begin to lose pleasure in anxiety-provoking activities, which results in the development of other depressive symptoms.
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