Limited value of uric acid to creatinine ratios in estimating uric acid excretion.
Limited value of uric acid to creatinine ratios in estimating uric acid excretion.
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DOI：
10.7326/0003-4819-93-6-822
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发表时间：
1980-12
影响因子：
39.2
通讯作者：
R. Wortmann;I. Fox
中科院分区：
文献类型：
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作者：
R. Wortmann;I. Fox
对49例酶活性正常的患者和22例嘌呤酶缺乏症患者的尿酸/肌酐比值和尿酸/肌酐清除率预测24小时尿酸排泄的价值进行了评价。9例次黄嘌呤-鸟嘌呤磷酸核糖基转移酶部分缺陷患者中有6例24小时尿酸/肌酐比值大于0.75，所有Lesch-Nyhan综合征患者均如此。比值小于0.10表示黄嘌呤尿症或严重的嘌呤核苷磷酸化酶缺乏症。从24小时样本的2小时定时采集计算的这两个比率与酶活性正常的患者的24小时尿尿酸排泄量都没有高度相关性，这可能是因为尿尿酸排泄的日变化。在酶活性正常的患者中，尿酸/肌酐比值不能准确预测24小时尿尿酸排泄量。
The value of the uric acid to creatinine ratio and the uric acid to creatinine clearance ratio in predicting 24-hour urinary uric acid excretion was assessed in 49 patients with normal enzyme activity and 22 patients with purine enzyme deficiencies. A 24-hour urinary uric acid to creatinine ratio greater than 0.75 was found in six of nine patients with a partial deficiency of hypoxanthine-guanine phosphoribosyltransferase and in all patients with Lesch-Nyhan syndrome. A ratio of less than 0.10 suggested xanthinuria or severe purine nucleoside phosphorylase deficiency. Neither ratio calculated from 2-hour timed collections of the 24-hour specimen showed a high correlation with 24-hour urine uric acid excretion in patients with normal enzyme activity, perhaps because of a diurnal variation in urinary uric acid excretion. The spot-urine uric acid to creatinine ratio does not accurately predict the 24-hour urine uric acid excretion in patients with normal enzyme activity.