Self-assembly and pH-responsive properties of poly(L-glutamic acid-r-L-leucine) and poly(L-glutamic acid-r-L-leucine)-b-polysarcosine
Self-assembly and pH-responsive properties of poly(L-glutamic acid-r-L-leucine) and poly(L-glutamic acid-r-L-leucine)-b-polysarcosine
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聚(L-谷氨酸-r-L-亮氨酸)和聚(L-谷氨酸-r-L-亮氨酸)-b-聚肌氨酸的自组装和pH响应特性
DOI：
10.1007/s10118-015-1669-0
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发表时间：
2015-06
影响因子：
4.3
通讯作者：
Shen, You-qing
中科院分区：
文献类型：
--
作者：
Tian, Ce;Ling, Jun;Shen, You-qing
多肽和类多肽因其良好的生物相容性而被广泛用作生物医用材料。本文报道了一系列具有pH响应性的共聚肽和多肽-类多肽嵌段共聚物，即L-谷氨酸（Glu）与L-亮氨酸（Leu）的无规共聚物[poly（Glu-r-Leu）s]，以及它们与聚肌氨酸（polySar）的嵌段共聚物。通过相应的N-羧酸酐单体的开环聚合，合成了具有可预测组成和分子量的结构明确的聚（Glu-r-Leu）。研究了共聚物组成与亲水性-疏水性转变的关系。随着Leu含量的增加，浊点pH值和胶束尺寸均增大。含60%Leu的Poly（Glu-r-Leu）在pH 5.0 ~ 6.0范围内具有与内体和溶酶体相同的浊点。Poly（Glu-r-Leu）-b-polySars在磷酸盐缓冲液中组装，可实现高pH时的球形胶束到低pH时的蠕虫状胶束的pH响应性形态变化，是一种潜在的pH响应性药物和基因递送载体，可促进细胞内货物的释放。
Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility. In this work we reported a series of pH-responsive copolypeptides and polypeptide-polypeptoid block copolymers,i.e. random copolymers of L-glutamic acid (Glu) with L-leucine (Leu) [poly(Glu-r-Leu)s], as well as their block copolymers with polysarcosine (polySar). Well-defined poly(Glu-r-Leu)s with predictable compositions and molecular weights were synthesized by ring opening polymerization of correspondingN-carboxyanhydride monomers. We investigated the relationship between hydrophilicity-hydrophobicity transition and copolymer composition. With increasing Leu fraction, both the pH value of cloud point and the micellar size increased. Poly(Glu-r-Leu) with 60% Leu exhibited a cloud point at the pH of 5.0 to 6.0 the same as that in endosome and lysosome. Poly(Glu-r-Leu)-b-polySars assembled in phosphate buffer and performed pH-responsive morphology change from orbicular micelles at high pH to worm-like micelles at low pH. They were potential pH-responsive carriers for drug and gene delivery to enhance cargo release in cellules.
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影响因子：
5.5
作者：
Huesmann, David;Birke, Alexander;Barz, Matthias
通讯作者：
Barz, Matthias
影响因子：
3.8
作者：
C. J. Beverung;C. Radke;H. Blanch
通讯作者：
C. J. Beverung;C. Radke;H. Blanch
DOI：
10.1002/chin.201410256
发表时间：
2014-03
期刊：
ChemInform
影响因子：
--
作者：
Hua Lu;J. Wang;Ziyuan Song;Lichen Yin;Yanfeng Zhang;Haoyu Tang;Chunlai Tu;Yao Lin;Jianjun Cheng
通讯作者：
Hua Lu;J. Wang;Ziyuan Song;Lichen Yin;Yanfeng Zhang;Haoyu Tang;Chunlai Tu;Yao Lin;Jianjun Cheng
影响因子：
64.8
作者：
Deming, TJ
通讯作者：
Deming, TJ
影响因子：
6.2
作者：
Birke, Alexander;Huesmann, David;Barz, Matthias
通讯作者：
Barz, Matthias