Social withdrawal and testosterone levels in early adolescent boys
Social withdrawal and testosterone levels in early adolescent boys
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青春期早期男孩的社交退缩和睾酮水平
DOI：
10.1016/j.psyneuen.2020.104596
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发表时间：
2020
影响因子：
3.7
通讯作者：
Kasai Kiyoto
中科院分区：
文献类型：
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作者：
Hayashi Noriyuki;Ando Shuntaro;Jinde Seiichiro;Fujikawa Shinya;Okada Naohiro;Toriyama Rie;Masaoka Mio;Sugiyama Hiroshi;Shirakawa Toru;Yagi Tomoko;Morita Masaya;Morishima Ryo;Kiyono Tomoki;Yamasaki Syudo;Nishida Atsushi;Kasai Kiyoto
社交退缩可能会导致心理健康问题，并对生命历程产生重大影响，尤其是对男孩而言。为了支持社交退缩的青少年，对生物学基础的综合理解将有所帮助。众所周知，社交支配力可能与社交退缩相反，它与睾酮水平呈正相关。先前的一项研究表明，青春期男孩的社交退缩与性成熟度呈负相关。然而，社交退缩与青春期睾酮之间的关系尚不清楚。本研究旨在探讨青春期早期男孩的社交退缩是否与睾酮水平呈负相关。唾液样本采集自 159 名健康的青春期早期男孩（平均年龄 [标准差]：11.5 [0.73]），这些男孩选自“东京青少年队列人口神经科学研究”（pn-TTC）的参与者。通过主要父母填写的自填问卷来评估社交退缩和混杂因素，例如第二性征及其年龄（以月为单位）。使用儿童行为检查表（CBCL）评估社交退缩程度。通过液相色谱-串联质谱法 (LC-MS/MS) 测量唾液睾酮和皮质醇水平作为对照。进行逻辑回归来检查社交退缩和睾酮水平之间的关联。调整年龄（以月为单位）后，较高的社交退缩风险与较低的唾液睾酮水平相关（比值比 0.55，95% 置信区间 0.33-0.94），并且在调整体重指数、焦虑/抑郁程度和青春期阶段后，这种关联仍然显着。因此，我们发现青春期早期男孩的社交退缩与睾酮水平之间存在负相关关系。这些发现可能有助于阐明社交退缩的生物学基础并为社交退缩提供支持。
Social withdrawal may lead to mental health problems and can have a large impact on a life course, particularly among boys. To support adolescents with social withdrawal, an integrative understanding of the biological bases would be helpful. Social dominance, a possible opposite of social withdrawal, is known to have positive associations with testosterone levels. A previous study suggested that social withdrawal has a negative relationship with sexual maturity among adolescent boys. However, the relationship between social withdrawal and testosterone in adolescence is unknown. This study aimed to examine whether social withdrawal was negatively associated with testosterone levels in early adolescent boys. Salivary samples were collected from 159 healthy early adolescent boys (mean age [standard deviation]: 11.5 [0.73]) selected from participants of the “population-neuroscience study of the Tokyo Teen Cohort” (pn-TTC). Social withdrawal and confounding factors, such as the secondary sexual characteristics and their age in months, were evaluated by self-administered questionnaires completed by the primary parents. The degree of social withdrawal was assessed with the Child Behaviour Checklist (CBCL). Levels of salivary testosterone, and cortisol as a control, were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Logistic regression was conducted to examine the association between social withdrawal and testosterone levels. A higher risk of social withdrawal was associated with a lower salivary testosterone level after adjustment for age in months (odds ratio 0.55, 95 % confidence interval 0.33-0.94), and the association remained significant after adjusting for body mass index, the degree of anxiety/depression and pubertal stage. Thus, we found a negative relationship between social withdrawal and testosterone levels in early adolescent boys. These findings may help to clarify the biological foundations of and to develop support for social withdrawal.