The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection.
The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection.
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小鼠巨细胞病毒肺部感染中病毒复制与间质性肺炎的关系。
DOI：
10.1093/infdis/151.3.454
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Pesanti,EL
中科院分区：
文献类型：
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作者：
Shanley,JD;Pesanti,EL
使用小鼠巨细胞病毒（MCMV）间质性肺炎的小鼠模型，我们研究了肺部病毒含量与肺部疾病之间的关系。虽然单独使用MCMV不会导致肺部疾病，但所有接受MCMV和单剂量环磷酰胺的小鼠均出现间质性肺炎。在这种情况下，通过肺湿重的增加来判断疾病的严重程度，与肺中的病毒含量成正比。尽管阿昔洛韦（50 mg/kg/天）和被动抗体给药均使肺组织中MCMV滴度降低> 90%，但所有动物均存在间质性肺炎的组织学证据。然而，两种病毒抑制剂都降低了治疗小鼠间质性肺炎的严重程度。虽然MCMV感染后宿主免疫的短暂改变是诱导间质性肺炎所必需的，但间质性肺炎的严重程度似乎反映了病毒复制的负担。减少病毒生长不能预防，但可能减轻MCMV间质性肺炎。
Using a murine model of murine cytomegalovirus (MCMV) interstitial pneumonitis, we examined the relation between the virus content of the lung and lung disease. While MCMV alone does not cause lung disease, interstitial pneumonitis was present in all mice receiving both MCMV and a single dose of cyclophosphamide. In this case the severity of disease, judged by increases in wet weight of the lung, was proportional to the virus content of the lung. Although both acyclovir (50 mg/kg per day) and passive antibody administration reduced the MCMV titers in lung tissues by >90%, histological evidence of interstitial pneumonitis was present in all animals. However, both virus inhibitors reduced the severity of interstitial pneumonitis in treated mice. While transient alterations in host immunity are necessary to induce interstitial pneumonitis after MCMV infection, the severity of interstitial pneumonitis seems to reflect the burden of virus replication. Reduction of virus growth does not prevent, but may moderate, MCMV interstitial pneumonitis.