Eosinophilic sialodochitis: a type of chronic obstructive sialadenitis related to allergy
Eosinophilic sialodochitis: a type of chronic obstructive sialadenitis related to allergy
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嗜酸性粒细胞性唾液腺炎：一种与过敏相关的慢性阻塞性唾液腺炎
DOI：
10.1002/lary.28772
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发表时间：
--
期刊：
影响因子：
2.6
通讯作者：
Guang-Yan Yu
中科院分区：
文献类型：
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作者：
Wen-Xuan Zhu;Yan Chen;Deng-Gao Liu;Guang-Yan Yu
目的探讨嗜酸性唾液根炎（ES）的临床、实验室、影像学、组织病理学和免疫组织化学特征以及过敏相关细胞因子的表达。方法38例诊断为慢性阻塞性涎腺炎（COS）并行腺体切除或切口活检的患者入组。伴有特应性疾病合并导管组织嗜酸性粒细胞增多的患者17例为ES组，21例为COS组。比较两组患者的临床病理特征及过敏相关细胞因子的表达。结果ES组多累及双侧大涎腺，且腺数明显多于COS组（2.8±1.1比1.2±0.4，P< 0.001）。ES组91%患者血清免疫球蛋白（Ig） E升高（419±357 kU/L），外周血嗜酸性粒细胞显著高于COS组（7.6%±4.6% vs. 2.5%±1.4%，P< 0.001）。组织学上，ES组主要小叶间管周围可见嗜酸性粒细胞浸润（50±39/高倍视野[HPF]）。观察到滤泡增生（76%）、上皮性粘膜化生（82%）和黏液塞伴嗜酸性粒细胞（41%）。IgE阳性细胞数为20.7±18.3/HPF，胰蛋白酶阳性肥大细胞数为23.5±15.1/HPF，均显著高于COS组，且主要浸润于导管周围。ES组组织中白细胞介素- 4、白细胞介素- 13和eotaxin的水平明显高于COS组。结论ES的临床病理特征与COS有明显差异，可能存在过敏相关的发病机制。证据水平[j] .喉镜杂志，31 (1):898 - 896,2011
ObjectivesTo investigate the clinical, laboratory, radiological, histopathological, and immunohistochemical features, and the expression of allergy‐related cytokines in eosinophilic sialodochitis (ES).MethodsThirty‐eight patients diagnosed with chronic obstructive sialadenitis (COS) who had undergone glandular excision or incisional biopsy were enrolled. Seventeen patients with comorbid atopic disease and increased ductal tissue eosinophils comprised the ES group, while 21 patients comprised the COS group. The clinicopathological features and allergy‐related cytokine expression were compared between groups.ResultsThe ES group frequently involved multiple, bilateral major salivary glands, and the number of glands was significantly greater than the COS group (2.8 ± 1.1 vs. 1.2 ± 0.4,P< .001). Serum immunoglobulin (Ig) E was elevated in 91% of patients in ES group (419 ± 357 kU/L) and peripheral blood eosinophil was significantly greater compared with the COS group (7.6% ± 4.6% vs. 2.5% ± 1.4%,P< .001). Histologically, eosinophil infiltration in ES group was observed around the main and interlobular ducts (50 ± 39/high power field [HPF]). Follicular hyperplasia (76%), epithelial mucous metaplasia (82%), and mucus plugs with eosinophils (41%) were observed. IgE‐positive cell count was 20.7 ± 18.3/HPF and tryptase‐positive mast cell count was 23.5 ± 15.1/HPF, which was significantly greater than the respective cell counts in COS group, which mainly infiltrated around the ducts. The levels of interleukin‐4, interleukin‐13, and eotaxin in tissue were significantly greater in ES than the COS group.ConclusionsThe clinicopathological characteristics of ES are significantly different from COS and ES might have an allergy‐related pathogenesis.Level of Evidence4Laryngoscope, 131:E800–E806, 2021