Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study.
Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study.
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发表时间：
2003-09
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通讯作者：
Jian-Min Yuan;D. Stram;Kazuko Arakawa;Hin‐Peng Lee;Mimi C. Yu
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作者：
Jian-Min Yuan;D. Stram;Kazuko Arakawa;Hin‐Peng Lee;Mimi C. Yu
中国最近在上海对中国男性进行的一项队列研究发现，诊断前血清β-隐黄素水平高与肺癌风险降低有关。关于饮食中的β-隐黄素以及其他特定的类胡萝卜素和抗氧化剂与肺癌有关的数据很少，特别是在非西方人群中。本研究的目的是评估饮食中抗氧化剂在肺癌发生中的作用。1993年4月至1998年12月，在新加坡的63257名年龄在45-74岁的中国男性和女性参与了一项关于饮食与癌症的前瞻性研究。在基线时，使用结构化问卷进行面对面访谈，以了解有关日常饮食习惯、吸烟和其他生活方式因素的信息。新加坡食物成分数据库被用来估计研究对象的α-胡萝卜素、β-胡萝卜素、β-隐黄素、番茄红素、叶黄素/玉米黄质、维生素A、C和E以及叶酸的摄入量。在前8年的随访中，队列成员中发生了482例肺癌病例。饮食中高水平的β-隐黄素与肺癌风险降低相关；相对于最低的五分之一，所有受试者中最高五分之一的自我报告吸烟调整后的相对风险(95%可信区间)在所有受试者中为0.73(0.54-0.98)，在当前吸烟者中为0.63(0.41-0.99)。在对吸烟进行调整之前，饮食中的维生素C与肺癌风险的统计显著降低有关。然而，吸烟和饮食中的β-隐黄素在很大程度上解释了维生素C与肺癌的反向关联。调整吸烟因素后，其他类胡萝卜素(α-胡萝卜素、β-胡萝卜素、番茄红素、叶黄素/玉米黄质)、维生素A、维生素E以及叶酸与肺癌风险无明显关联。我们认识到，吸烟中潜在的测量误差可能会对饮食中的β-隐黄素-肺癌相关性产生影响。在使用统计模型对吸烟造成的残留混杂进行额外调整后，饮食中β-隐黄素含量最高的10%的受试者患肺癌的风险比饮食中最低10%的受试者降低了约15%-40%。本研究补充了先前的实验和流行病学数据，支持饮食中的β-隐黄素是人类肺癌的化学预防药物的假说。
High prediagnostic serum beta-cryptoxanthin levels have been found to be associated with reduced risk of lung cancer in a recent cohort study of Chinese men in Shanghai, China. Data on dietary beta-cryptoxanthin, and other specific carotenoids and antioxidants in relation to lung cancer, particularly in non-Western populations, are scarce. The aim of the present study was to assess the roles of dietary antioxidants in the development of lung cancer. Between April 1993 and December 1998, 63,257 Chinese men and women ages 45-74 years in Singapore participated in a prospective study of diet and cancer. At baseline, an in-person interview was conducted using a structured questionnaire for information on usual dietary habits, tobacco smoking, and other lifestyle factors. A Singapore food composition database was used to estimate intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, vitamins A, C, and E, and folate in study subjects. During the first 8 years of follow-up, 482 lung cancer cases occurred among cohort members. High levels of dietary beta-cryptoxanthin were associated with reduced risk of lung cancer; relative to the lowest quintile, the self-reported smoking adjusted relative risks (95% confidence intervals) for the highest quintile were 0.73 (0.54-0.98) among all of the subjects and 0.63 (0.41-0.99) among current smokers. Before adjustment for cigarette smoking, dietary vitamin C was associated with a statistically significant reduction in risk of lung cancer. However the inverse vitamin C-lung cancer association was largely explained by smoking and dietary beta-cryptoxanthin. Other carotenoids (alpha-carotene, beta-carotene, lycopene, and lutein/zeaxanthin), vitamins A and E, and folate were not associated significantly with lung cancer risk after adjustment for cigarette smoking. We recognized that potential measurement errors in cigarette smoking may exert an effect on the dietary beta-cryptoxanthin-lung cancer association. After additional adjustments were made for the residual confounding by smoking using statistical models, about 15-40% reduction in risk of lung cancer was seen for subjects in the highest versus lowest 10th percentile of dietary beta-cryptoxanthin. The present study lends additional credence to prior experimental and epidemiological data in support of the hypothesis that dietary beta-cryptoxanthin is a chemopreventive agent for lung cancer in humans.